Evidence map›Paper›PMID 31322997›Full record

ArticleMolecular biology of the cell2019

Biophysics at the coffee shop: lessons learned working with George Oster.

Oleg A Igoshin, Jing Chen, Jianhua Xing, Jian Liu, Timothy C Elston, Michael Grabe, Kenneth S Kim, Jasmine A Nirody, Padmini Rangamani, Sean X Sun and 2 more

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Mathematical Modeling of Plasticity and Heterogeneity in EMT.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Oleg A IgoshinDepartments of Bioengineering, Biosciences, and Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.
Jing ChenDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061.
Jianhua XingDepartment of Computational and Systems Biology and UPMC-Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Jian LiuDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Timothy C ElstonDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Michael GrabeCardiovascular Research Institute, School of Pharmacy, University of California, San Francisco, San Francisco, CA 94158.
Kenneth S KimLawrence Livermore National Laboratory, Livermore, CA 94550.
Jasmine A NirodyCenter for Studies in Physics and Biology, Rockefeller University, New York, NY 10065.
Padmini RangamaniDepartment of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093.
Sean X SunDepartment of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218.
Hongyun WangDepartment of Applied Mathematics and Statistics, University of California, Santa Cruz, Santa Cruz, CA 95064.
Charles WolgemuthDepartment of Physics and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721.

Funding

The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2016 to 2020
$9.9M
Mathematical modeling of cellular signaling systemsR35GM127145 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Timothy C Elston · 2018 to 2026
$3.9M
The Role of Osmotic Engine in Confined MigrationR01GM114675 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, SUN, SEAN X · 2015 to 2018
$1.3M
NCI NIH HHS U54 CA210173NIGMS NIH HHS R01 GM114675NIGMS NIH HHS R35 GM127145
6 · The paper itself

Abstract

Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that his sharp intellect, physical intuition, and passion for scientific inquiry not only inspired us as scientists but also greatly influenced the way we conduct research. We would like to share a few important lessons we learned from George in honor of his memory and with the hope that they may inspire future generations of scientists.

Indexed as

BiophysicsAnimalsHumansModels, Theoretical

Identifiers

PMID31322997
PMCPMC6727762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.