ArticleJournal of the American Chemical Society2019
Bright G-Quadruplex Nanostructures Functionalized with Porphyrin Lanterns.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Cucurbit[6]uril-monoazide: towards functional CB[6]-tethered DNA (pseudo)rotaxanes.Chemical science · 2026Article
- TMPyP binding evokes a complex, tunable nanomechanical response in DNA.Nucleic acids research · 2024Article
- Heteromeric guanosine (G)-quadruplex derived antenna modules with directional energy transfer.Nanoscale · 2023Article
- Pursuing excitonic energy transfer with programmable DNA-based optical breadboards.Chemical Society reviews · 2023Review
- Unraveling the Possibilities: Recent Progress in DNA Biosensing.Biosensors · 2023Review
- Two birds one stone: β-fluoropyrrolyl-cysteine SChemical science · 2023Article
- CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview.Beilstein journal of organic chemistry · 2023Review
- A Photoacoustic Contrast Agent for miR-21 via NIR Fluorescent Hybridization Chain Reaction.Bioconjugate chemistry · 2022Article
- Understanding self-assembly at molecular level enables controlled design of DNA G-wires of different properties.Nature communications · 2022Article
- Metallointercalators-DNA Tetrahedron Supramolecular Self-Assemblies with Increased Serum Stability.ACS nano · 2022Article
- Measurement of Single-Molecule Forces in Cholesterol and Cyclodextrin Host-Guest Complexes.The journal of physical chemistry. B · 2021Article
- Synthesis and Applications of Porphyrin-Biomacromolecule Conjugates.Frontiers in chemistry · 2021Review
- Single-Molecule Mechanics in Ligand Concentration Gradient.Micromachines · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The intricate arrangement of numerous and closely placed chromophores on nanoscale scaffolds can lead to key photonic applications ranging from optical waveguides and antennas to signal-enhanced fluorescent sensors. In this regard, the self-assembly of dye-appended DNA sequences into programmed photonic architectures is promising. However, the dense packing of dyes can result in not only compromised DNA assembly (leading to ill-defined structures and precipitates) but also to essentially nonfluorescent systems (due to π-π aggregation). Here, we introduce a two-step "tether and mask" strategy wherein large porphyrin dyes are first attached to short G-quadruplex-forming sequences and then reacted with per-O-methylated β-cyclodextrin (PMβCD) caps, to form supramolecular synthons featuring the porphyrin fluor fixed into a masked porphyrin lantern (PL) state, due to intramolecular host-guest interactions in water. The PL-DNA sequences can then be self-assembled into cyclic architectures or unprecedented G-wires tethered with hundreds of porphyrin dyes. Importantly, despite the closely arrayed PL units (∼2 nm), the dyes behave as bright chromophores (up to 180-fold brighter than the analogues lacking the PMβCD masks). Since other self-assembling scaffolds, dyes, and host molecules can be used in this modular approach, this work lays out a general strategy for the bottom-up aqueous self-assembly of bright nanomaterials containing densely packed dyes.
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Registered trials
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