ArticleDrug development research2019
Mucosal gene expression changes induced by anti-TNF treatment in inflammatory bowel disease patients.
Article in Drug development research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Mucosal Genes Expression in Inflammatory Bowel Disease Patients: New Insights.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Mucosal gene expression profile of stricturing Crohn's disease: A preliminary study.Experimental and therapeutic medicine · 2022Article
- LCN2 as a Potential Diagnostic Biomarker for Ulcerative Colitis-Associated Carcinogenesis Related to Disease Duration.Frontiers in oncology · 2021Article
- Diagnosis and Psychotherapeutic Needs by Early Maladaptive Schemas in Patients With Inflammatory Bowel Disease.Frontiers in psychology · 2021Article
- The Interplay between Mucosal Microbiota Composition and Host Gene-Expression is Linked with Infliximab Response in Inflammatory Bowel Diseases.Microorganisms · 2020Article
- Can molecular stratification improve the treatment of inflammatory bowel disease?Pharmacological research · 2019Review
- Mucosal gene expression changes induced by anti-TNF treatment in inflammatory bowel disease patients.Drug development research · 2019Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last two decades anti-tumor necrosis factor (anti-TNF) therapy for inflammatory bowel disease (IBD) has been widely used to induce and maintain clinical and endoscopical remission, completely changing management of the disease. In this study, we aimed to identify gene expression changes in inflamed mucosa from Crohn's disease and ulcerative colitis patients treated with 5-aminosalicylic acid (5-ASA) (N = 25) or anti-TNF agents (N = 12) compared to drug-free IBD patients (N = 12) and non-IBD control subjects (N = 18). The mucosal expression of 84 genes previously associated with IBD was evaluated by qPCR. We found that both therapeutic regimens induce a decrease in LCN2, NOS2, and TFF1, the levels of which are overexpressed in drug-free patients compared to non-IBD control subjects. Interestingly, a stronger effect of anti-TNF drugs was observed on LCN2 and TFF1 levels. However, 5-ASA seems to induce a more robust reduction of NOS2 expression. Moreover, we found that anti-TNF treatment significantly increased ABCB1, leading to levels similar to those found in non-IBD control subjects.
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Registered trials
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