Evidence map›Paper›PMID 31322613›Full record

ArticleClinical journal of oncology nursing2019

GATA2 Deficiency: Early Identification for Improved Clinical Outcomes.

Kristen Cole, Daniele Avila, Mark Parta, Bazetta Schuver, Steven Holland, Nirali Shah, Dennis Hickstein

Open access · greenAbstract readCase Reports
In one paragraph

Article in Clinical journal of oncology nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kristen ColeCenter for Cancer Research at the National Cancer Institute.
Daniele AvilaCenter for Cancer Research at the National Cancer Institute.
Mark PartaFrederick National Laboratory for Cancer Research.
Bazetta SchuverCenter for Cancer Research at the National Cancer Institute.
Steven HollandNational Institute of Allergy and Infectious Diseases.
Nirali ShahCenter for Cancer Research at the National Institutes of Health.
Dennis HicksteinCenter for Cancer Research at the National Institutes of Health.
Office of the Director · USFrederick National Laboratory for Cancer Research · USNational Institute of Allergy and Infectious Diseases · US

Funding

Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Hematopoietic Stem Cell Gene Therapy for Leukocyte Adhesion DeficiencyZIASC010384 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI HICKSTEIN, DENNIS · 2009 to 2025
$7.2M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA SC010384NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

backgroundPatients with GATA2 deficiency present with nontuberculous mycobacterial infections, severe viral infections (particularly refractory human papillomavirus disease), lymphedema, myelodysplastic syndrome (MDS), and acute myeloid leukemia. Patients with GATA2 deficiency who undergo allogeneic hematopoietic stem cell transplantation prior to the development of life-threatening infections or cytogenetic abnormalities may have optimal clinical outcomes.

objectivesThe aim of this article is to determine ways in which oncology nurses can identify GATA2 deficiency in patients early and optimize treatment decisions.

methodsA case study is presented of a 33-year-old man with recurrent infections and MDS and his two sons, all of whom were found to have the same GATA2 mutation.

findingsOncology nurses play an important role in early detection and identification by interviewing patients and obtaining a complete and thorough family history.

Indexed as

Treatment OutcomeAdultFemaleGATA2 Transcription FactorHematopoietic Stem Cell TransplantationHumansMaleMyelodysplastic SyndromesOncology NursingGATA2 protein, humanGATA2 Transcription Factoracute myeloid leukemiaGATA2 deficiencymyelodysplastic syndrome

Identifiers

PMID31322613
PMCPMC8549740
OpenAlexW2962925874

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.