Evidence map›Paper›PMID 31322562›Full record

ArticleJournal of Alzheimer's disease : JAD2019

Handgrip Strength Is Associated with Poorer Cognitive Functioning in Aging Americans.

Ryan McGrath, Sheria G Robinson-Lane, Summer Cook, Brian C Clark, Stephen Herrmann, Melissa Lunsman O'Connor, Kyle J Hackney

Abstract read
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In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  3. The handgrip strength and risk of depressive symptoms: a meta-analysis of prospective cohort studies.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan McGrathDepartment of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA.
Sheria G Robinson-LaneSchool of Nursing, University of Michigan, Ann Arbor, MI, USA.
Summer CookDepartment of Kinesiology, University of New Hampshire, Durham, NH, USA.
Brian C ClarkOhio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH, USA.
Stephen HerrmannSanford Research, Sioux Falls, SD, USA.
Melissa Lunsman O'ConnorDepartment of Human Development and Family Science, North Dakota State University, Fargo, ND, USA.
Kyle J HackneyDepartment of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA.

Funding

Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1M
Neural mechanisms of dynapeniaR01AG044424 · NIA · OHIO UNIVERSITY ATHENS · PI CLARK, BRIAN C · 2014 to 2018
$1.4M
NIA NIH HHS P30 AG053760NIA NIH HHS R01 AG044424
6 · The paper itself

Abstract

backgroundMeasures of handgrip strength may show promise for detecting cognitive erosion during aging.

objectiveTo determine the associations between lower handgrip strength and poorer cognitive functioning for aging Americans.

methodsThere were 13,828 participants aged at least 50 years from the 2006 wave of the Health and Retirement Study included and followed biennially for 8 years. Handgrip strength was assessed with a hand-held dynamometer and cognitive functioning was assessed with a modified version of the Mini-Mental State Examination. Participants aged <65 years with scores 7- 11 had a mild cognitive impairment, ≤6 had a severe cognitive impairment, and ≤11 had any cognitive impairment. Respondents aged ≥65 years with scores 8- 10 had a mild cognitive impairment, ≤7 had a severe cognitive impairment, and ≤10 had any cognitive impairment. Separate covariate-adjusted multilevel logistic models examined the associations between lower handgrip strength and any or severe cognitive impairment. A multilevel ordered logit model analyzed the association between lower handgrip strength and poorer cognitive functioning.

resultsEvery 5-kg lower handgrip strength was associated with 1.10 (95% confidence interval (CI): 1.04, 1.15) and 1.18 (CI: 1.04, 1.32) greater odds for any and severe cognitive impairment, respectively. Similarly, every 5-kg lower handgrip strength was associated with 1.10 (CI: 1.05, 1.14) greater odds for poorer cognitive functioning.

conclusionsMeasurement of handgrip strength is a simple, risk-stratifying method for helping healthcare providers determine poorer cognitive functioning. Interventions aiming to prevent or delay cognitive dysfunction should also implement measures of handgrip strength as an assessment tool for determining efficacy.

Indexed as

AgedAged, 80 and overAgingCognitive DysfunctionCohort StudiesFemaleHand StrengthHumansMaleMiddle AgedUnited StatesAlzheimer’s diseasecognitiondementiafrailtygeriatricsmuscle strengthmuscle weakness

Identifiers

PMID31322562
PMCPMC9483826

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.