Evidence map›Paper›PMID 31322498›Full record

ArticleeLife2019

Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors.

Morgan Thompson, Ryan Bixby, Robert Dalton, Alexa Vandenburg, John A Calarco, Adam D Norris

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  11. mRNA initiation and termination are spatially coordinated.bioRxiv : the preprint server for biology · 2024
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  16. VISTA: Visualizing the Spatial Transcriptome of thebioRxiv : the preprint server for biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Morgan ThompsonBiological Sciences, Southern Methodist University, Dallas, United States.
Ryan BixbyBiological Sciences, Southern Methodist University, Dallas, United States.
Robert DaltonBiological Sciences, Southern Methodist University, Dallas, United States.
Alexa VandenburgBiological Sciences, Southern Methodist University, Dallas, United States.
John A CalarcoCell & Systems Biology, University of Toronto, Toronto, Canada.ORCID 0000-0002-2197-7801
Adam D NorrisBiological Sciences, Southern Methodist University, Dallas, United States.ORCID 0000-0002-0570-7414
Southern Methodist University · USUniversity of Toronto · CA

Funding

Dissecting RNA regulation in single cells and tissuesR35GM133461 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Adam Norris · 2019 to 2026
$3.1M
NIGMS NIH HHS R35 GM133461
6 · The paper itself

Abstract

Single-cell transcriptomes are established by transcription factors (TFs), which determine a cell's gene-expression complement. Post-transcriptional regulation of single-cell transcriptomes, and the RNA binding proteins (RBPs) responsible, are more technically challenging to determine, and combinatorial TF-RBP coordination of single-cell transcriptomes remains unexplored. We used fluorescent reporters to visualize alternative splicing in single

Indexed as

Gene Expression RegulationRNA SplicingAnimalsCaenorhabditis elegansGenes, ReporterIntracellular Signaling Peptides and ProteinsMicroscopy, FluorescenceNeuronsProtein Serine-Threonine KinasesRNA-Binding ProteinsTranscription FactorsIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesRNA-Binding Proteinssad-1 protein, C elegansTranscription FactorsC. elegansdevelopmental biologygeneticsgenomicsRNAsingle neuronsplicing

Identifiers

PMID31322498
PMCPMC6641836
OpenAlexW2963836763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.