Evidence map›Paper›PMID 31322481›Full record

ArticleEpigenetics2019

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant

Omid Fotouhi, Mehran Ghaderi, Na Wang, Jan Zedenius, Magnus Kjellman, Dawei Xu, C Christofer Juhlin, Catharina Larsson

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Omid FotouhiDepartment of Oncology-Pathology, Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0003-0019-0230
Mehran GhaderiDepartment of Oncology-Pathology, Karolinska Institutet , Stockholm , Sweden.
Na WangDepartment of Oncology-Pathology, Karolinska Institutet , Stockholm , Sweden.
Jan ZedeniusDepartment of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm , Sweden.
Magnus KjellmanDepartment of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm , Sweden.
Dawei XuDepartment of Medicine, Division of Hematology (D.X.), Karolinska University Hospital , Stockholm , Sweden.
C Christofer JuhlinDepartment of Oncology-Pathology, Karolinska Institutet , Stockholm , Sweden.ORCID 0000-0002-5945-9081
Catharina LarssonDepartment of Oncology-Pathology, Karolinska Institutet , Stockholm , Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere maintenance is a critical requirement for enabling replicative immortality and tumour development. Here, telomerase expression and activity, telomere length (TL) and potential regulatory factors that can underlie telomerase machinery alterations in small intestinal neuroendocrine tumours (SI-NETs) were analyzed. Telomerase activity assessed by TRAP assay was increased in SI-NETs compared to normal ileum (

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticHEK293 CellsHumansIntestinal NeoplasmsLong Interspersed Nucleotide ElementsMutationNeuroendocrine TumorsPromoter Regions, GeneticTelomeraseTelomere HomeostasisTelomeraseTERT protein, humanDNA methylationSI-NETtelomeraseTelomereTERT

Identifiers

PMID31322481
PMCPMC6791720
OpenAlexW2963309473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.