Evidence map›Paper›PMID 31322427›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy.

Siamak Salavatian, Naoko Yamaguchi, Jonathan Hoang, Nicole Lin, Saloni Patel, Jeffrey L Ardell, J Andrew Armour, Marmar Vaseghi

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026
    Review
  2. Article
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  8. Alterations of sarcoplasmic reticulum-mediated CaMolecular and cellular biochemistry · 2023
    Article
  9. Review
  10. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  11. Article
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  13. Article
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  15. Review
  16. Hemodynamic assessment of diastolic function for experimental models.American journal of physiology. Heart and circulatory physiology · 2020
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Siamak SalavatianUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Naoko YamaguchiUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Jonathan HoangUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Nicole LinUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Saloni PatelUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Jeffrey L ArdellUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
J Andrew ArmourUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Marmar VaseghiUniversity of California, Los Angeles Cardiac Arrhythmia Center, Los Angeles, California.
Texas Cardiac Arrhythmia · USUniversity of California, Los Angeles · US

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
Cardiac Afferent Neurotransmission and Modulation of Ventricular Parasympathetic ControlDP2HL132356 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VASEGHI, MARMAR · 2015 to 2015
$2.3M
NHLBI NIH HHS DP2 HL132356NIH HHS OT2 OD023848
6 · The paper itself

Abstract

Mechanisms behind development of premature ventricular contraction (PVC)-induced cardiomyopathy remain unclear. PVCs may adversely modulate the autonomic nervous system to promote development of heart failure. Afferent neurons in the inferior vagal (nodose) ganglia transduce cardiac activity and modulate parasympathetic output. Effects of PVCs on cardiac parasympathetic efferent and vagal afferent neurotransmission are unknown. The purpose of this study was to evaluate effects of PVCs on vagal afferent neurotransmission and compare these effects with a known powerful autonomic modulator, myocardial ischemia. In 16 pigs, effects of variably coupled PVCs on heart rate variability (HRV) and vagal afferent neurotransmission were evaluated. Direct nodose neuronal recordings were obtained in vivo, and cardiac-related afferent neurons were identified based on their response to cardiovascular interventions, including ventricular chemical and mechanical stimuli, left anterior descending (LAD) coronary artery occlusion, and variably coupled PVCs. On HRV analysis before versus after PVCs, parasympathetic tone decreased (normalized high frequency: 83.6 ± 2.8 to 72.5 ± 5.3;

Indexed as

Heart RateMyocardial ContractionAnimalsCardiomyopathiesChemoreceptor CellsDisease Models, AnimalHeartMechanoreceptorsMyocardial IschemiaNodose GanglionSus scrofaSynaptic TransmissionTime FactorsVagus NerveVentricular Premature Complexesafferentautonomicnodose gangliaparasympatheticpremature ventricular contractionsvagus nerve

Identifiers

PMID31322427
PMCPMC6766725
OpenAlexW2963478461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.