Evidence map›Paper›PMID 31322419›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Krt5

Ashley R Jackson, Monica L Hoff, Birong Li, Christina B Ching, Kirk M McHugh, Brian Becknell

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Urothelial progenitors in development and repair.Pediatric nephrology (Berlin, Germany) · 2022
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ashley R JacksonNephrology Urology Research Affinity Group, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Monica L HoffNephrology Urology Research Affinity Group, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Birong LiNephrology Urology Research Affinity Group, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Christina B ChingNephrology Urology Research Affinity Group, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Kirk M McHughNephrology Urology Research Affinity Group, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Brian BecknellNephrology Urology Research Affinity Group, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.ORCID 0000-0002-2750-4415
Nationwide Children's Hospital · US

Funding

Urothelial IL-6 Signaling in the Host Defense Against Urinary Tract InfectionsK08DK122119 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CHING, CHRISTINA B · 2019 to 2023
$891k
Role of urothelium in epithelial integrity and innate defense of the kidneyK08DK102594 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BECKNELL, BRIAN · 2015 to 2019
$745k
Context Specific Roles of Renal Urothelial Cells in Development and Obstructive NephropathyF32DK115085 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI JACKSON, ASHLEY R. · 2017 to 2019
$179k
NIDDK NIH HHS F32 DK115085NIDDK NIH HHS K08 DK102594NIDDK NIH HHS K08 DK122119
6 · The paper itself

Abstract

Congenital urinary tract obstruction (UTO) is the leading cause of chronic kidney disease in children; however, current management strategies do not safeguard against progression to end-stage renal disease, highlighting the need for interventions to limit or reverse obstructive nephropathy. Experimental UTO triggers renal urothelial remodeling that culminates in the redistribution of basal keratin 5-positive (Krt5

Indexed as

Cell DifferentiationRegenerationAnimalsCell LineageDisease Models, AnimalEpithelial CellsFemaleGene Expression Regulation, DevelopmentalGestational AgeKeratin-15KidneyKidney DiseasesMaleMice, KnockoutOrganogenesisStem CellsKeratin-15Krt15 protein, mouseUroplakinskeratin 5kidney developmentlineage analysisrenal urotheliumurinary tract obstructionuroplakinurothelial plaqueurothelial progenitorurothelial remodeling

Identifiers

PMID31322419
PMCPMC6766634
OpenAlexW2963087698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.