Evidence map›Paper›PMID 31322326›Full record

ArticleStem cells translational medicine2019

Human Cord Blood-Derived Unrestricted Somatic Stem Cell Infusion Improves Neurobehavioral Outcome in a Rabbit Model of Intraventricular Hemorrhage.

Govindaiah Vinukonda, Yanling Liao, Furong Hu, Larisa Ivanova, Deepti Purohit, Dina A Finkel, Priyadarshani Giri, Lakshmipramoda Bapatla, Shetal Shah, Muhammed T Zia and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026
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  10. The role of stem cells in the management of neonatal posthemorrhagic hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Govindaiah VinukondaDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.ORCID 0000-0002-6065-3092
Yanling LiaoDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Furong HuDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Larisa IvanovaDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Deepti PurohitThe Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA.
Dina A FinkelThe Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA.
Priyadarshani GiriThe Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA.
Lakshmipramoda BapatlaCell Biology & Anatomy, New York Medical College, Valhalla, New York, USA.
Shetal ShahDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Muhammed T ZiaThe Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA.
Karen HusseinDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Mitchell S CairoDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.ORCID 0000-0002-2075-434X
Edmund F La GammaDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
New York Medical College · USMaria Fareri Children's Hospital · USWestchester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraventricular hemorrhage (IVH) is a severe complication of preterm birth, which leads to hydrocephalus, cerebral palsy, and mental retardation. There are no available therapies to cure IVH, and standard treatment is supportive care. Unrestricted somatic stem cells (USSCs) from human cord blood have reparative effects in animal models of brain and spinal cord injuries. USSCs were administered to premature rabbit pups with IVH and their effects on white matter integrity and neurobehavioral performance were evaluated. USSCs were injected either via intracerebroventricular (ICV) or via intravenous (IV) routes in 3 days premature (term 32d) rabbit pups, 24 hours after glycerol-induced IVH. The pups were sacrificed at postnatal days 3, 7, and 14 and effects were compared to glycerol-treated but unaffected or nontreated control. Using in vivo live bioluminescence imaging and immunohistochemical analysis, injected cells were found in the injured parenchyma on day 3 when using the IV route compared to ICV where cells were found adjacent to the ventricle wall forming aggregates; we did not observe any adverse events from either route of administration. The injected USSCs were functionally associated with attenuated microglial infiltration, less apoptotic cell death, fewer reactive astrocytes, and diminished levels of key inflammatory cytokines (TNFα and IL1β). In addition, we observed better preservation of myelin fibers, increased myelin gene expression, and altered reactive astrocyte distribution in treated animals, and this was associated with improved locomotor function. Overall, our findings support the possibility that USSCs exert anti-inflammatory effects in the injured brain mitigating many detrimental consequences associated with IVH. Stem Cells Translational Medicine 2019;8:1157-1169.

Indexed as

Behavior, AnimalDisease Models, AnimalAdult Stem CellsAnimalsCerebral HemorrhageCord Blood Stem Cell TransplantationFetal BloodHumansNeurocognitive DisordersNeuropsychological TestsRabbitsBioluminescence imagingIntraventricular hemorrhageLocomotor functionMyelinationUnrestricted somatic stem cells (USSCs)White matter injury

Identifiers

PMID31322326
PMCPMC6811700
OpenAlexW2963793757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.