ArticleObesity (Silver Spring, Md.)2019
Obesity Tissue: Composition, Energy Expenditure, and Energy Content in Adult Humans.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Comparisons of calorie restriction and structured exercise on reductions in visceral and abdominal subcutaneous adipose tissue: a systematic review.European journal of clinical nutrition · 2022Pooled it
- The magnitude and progress of lean body mass, fat-free mass, and skeletal muscle mass loss following bariatric surgery: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Body Composition Changes after a Weight Loss Intervention: A 3-Year Follow-Up Study.Nutrients · 2021Trial
- Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.Journal of cachexia, sarcopenia and muscle · 2026Review
- Tissue-Specific Multi-Omics Integration Demonstrates Molecular Signatures Connecting Obesity to Immune Vulnerability.Metabolites · 2026Article
- Diagnosis of chronic fatigue syndrome using beat-to-beat autonomic measurements.Journal of translational medicine · 2025Article
- Visualization obesity risk prediction system based on machine learning.Scientific reports · 2024Article
- Measurement of Energy Expenditure by Indirect Calorimetry with a Whole-Room Calorimeter.Phenomics (Cham, Switzerland) · 2024Article
- Energy homeostasis from Lavoisier to control theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- An adiposity force induces obesity in humans independently of a normal energy balance system-a thought experiment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.Clinical pharmacokinetics · 2022Article
- Characterizing Pharmacokinetics in Children With Obesity-Physiological, Drug, Patient, and Methodological Considerations.Frontiers in pharmacology · 2022Review
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- Simple Skeletal Muscle Mass Estimation Formulas: What We Can Learn From Them.Frontiers in endocrinology · 2020Article
- The effectiveness of self-empowerment-based patient-centered care for obese students in primary services: A randomized controlled trial.Journal of family & community medicineArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveChronic positive energy balance leads to obesity, and the "excess" weight is usually described as consisting solely of adipose tissue (AT) or its two components, fat and fat-free mass (nonfat cell mass, extracellular fluid). This study aimed to clarify the nature of "obesity" tissue.
methodsA total of 333 adults had AT, skin, skeletal muscle, bone, heart, liver, kidney, spleen, brain, and residual mass measured or derived using magnetic resonance imaging and dual-energy x-ray absorptiometry. First, associations between these components and AT were examined by developing multiple regression models. Next, obesity-tissue composition was developed by deriving mean component mass differences between participant groups with normal weight (BMI < 25 kg/m
resultsAT significantly predicted organ-tissue mass in 17 of 18 multiple regression models. In addition to AT and skeletal muscle, the following associations were found: skin, liver, and bone were main contributors to obesity-tissue composition; liver, kidneys, and heart to resting energy expenditure; and skin, liver, and bone to metabolizable energy and protein contents. A pronounced sexual dimorphism was present in all three models.
conclusionsObesity is characterized not only by excess AT but by increases in the masses of other "companion" organs and tissues and their related metabolic properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.