ArticleCancer medicine2019
Mycoplasma hyorhinis infection promotes gastric cancer cell motility via β-catenin signaling.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Tumor microenvironment dynamics in gastric cancer pathogenesis and therapeutic resistance.Molecular cancer · 2026Review
- Role of human microbiota in facilitating the metastatic journey of cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- 7,7-Bis(3-Indolyl)-Journal of microbiology and biotechnology · 2025Article
- Infectious Agents Induce Wnt/β-Catenin Pathway Deregulation in Primary Liver Cancers.Microorganisms · 2023Review
- Downregulated mitochondrial transcription factor A enhances mycoplasma infection to promote the metastasis of hepatocellular carcinoma.Cancer science · 2023Article
- Review
- Review
- Nucleic acid aptamer controls mycoplasma infection for inhibiting the malignancy of esophageal squamous cell carcinoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Oropharynx microbiota transitions in hypopharyngeal carcinoma treatment of induced chemotherapy followed by surgery.BMC microbiology · 2021Article
- Bacteria-Cancer Interface: Awaiting the Perfect Storm.Pathogens (Basel, Switzerland) · 2021Review
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) moonlights as an adhesin in Mycoplasma hyorhinis adhesion to epithelial cells as well as a plasminogen receptor mediating extracellular matrix degradation.Veterinary research · 2021Article
- The Relationship betweenJournal of oncology · 2021Review
- Role of Mycoplasma Chaperone DnaK in Cellular Transformation.International journal of molecular sciences · 2020Review
- Mycoplasma hyorhinis infection promotes gastric cancer cell motility via β-catenin signaling.Cancer medicine · 2019Article
- A Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers.Cancers · 2019Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe previously identified that Mycoplasma hyorhinis infection promotes gastric cancer cell motility. The β-catenin signaling pathway is critical to determining malignant cancer cell phenotypes; however, the association between M hyorhinis and the β-catenin signaling pathway is unclear.
methodsWe performed subcellular fractionation and immunofluorescence staining to observe β-catenin accumulation in the nucleus. The expression of downstream β-catenin genes was detected by quantitative RT-PCR. Gastric cancer cell motility was examined by transwell chamber migration and wound healing assays, and a co-immunoprecipitation assay was used to detect the proteins associated with the membrane protein p37 of M hyorhinis.
resultsWe found that M hyorhinis infection promoted nuclear β-catenin accumulation and enhanced the expression of downstream β-catenin genes. M hyorhinis-promoted gastric cancer cell motility was counteracted by treatment with the β-catenin inhibitor XAV939 or β-catenin knockdown. We further detected a protein complex containing LRP6, GSK3β, and p37 in M hyorhinis-infected cells. M hyorhinis also induced LRP6 phosphorylation in a GSK3β-dependent fashion. Knockdown of LRP6 or GSK3β abolished M hyorhinis-induced cell motility.
conclusionOur results reveal that the β-catenin signaling pathway could be activated by M hyorhinis infection, thereby contributing to M hyorhinis-induced gastric cancer cell motility.
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