ReviewJournal of endocrinological investigation2019
Epidemiology, pathogenesis, and diagnosis of Addison's disease in adults.
Review in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Health-related quality of life and patterns of psychological vulnerability in autoimmune Addison's disease: a systematic review.Frontiers in endocrinology · 2026Pooled it
- Susceptibility to Adrenal Crisis Is Associated With Differences in Cortisol Excretion in Patients With Secondary Adrenal Insufficiency.Frontiers in endocrinology · 2022Trial
- Micro- and macrovascular function in patients suffering from primary adrenal insufficiency: a cross-sectional case-control study.Journal of endocrinological investigation · 2021Trial
- Delay in Diagnosis of Addison's Disease: A Case Report and Literature Review.Clinical case reports · 2026Article
- Addison's disease in Italy: mortality and survival by etiology.Journal of endocrinological investigation · 2026Article
- Visual Hallucinations and Cognitive Impairment as the Initial Presentation of Severe Hypothyroidism in an Elderly Patient: A Case Report.Geriatrics (Basel, Switzerland) · 2026Article
- Work Loss and Income Before and After Diagnosis of Addison's Disease: A Population-Based Longitudinal Study.The Journal of clinical endocrinology and metabolism · 2026Article
- Type 1 Diabetes and Other Autoimmune Diseases-Epidemiology, Pathophysiology and Screening.Endocrinology, diabetes & metabolism · 2026Review
- An Intriguing Case Report of Type 2 Autoimmune Polyendocrine Syndrome Post-SARS-CoV-2: Cause or Coincidence?Endocrine, metabolic & immune disorders drug targets · 2026Review
- Primary adrenocortical insufficiency in patients with AIDS in Wuhan, China: 3 cases report and literature review.BMC infectious diseases · 2025Review
- Leukocytosis may be an indicator of replacement with supraphysiological dose in adrenal insufficiency: relationship with comorbidities and impaired muscle strength.Journal of endocrinological investigation · 2025Article
- Article
- Addison's disease due to adrenal insufficiency in an immunocompetent patient with disseminated cryptococcosis. Case report.Revista peruana de medicina experimental y salud publica · 2025Article
- Pregnancy Outcomes in Women With Primary Adrenal Insufficiency: Data From a Multicentre Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Prevalence of Various Systemic and Organ-Specific Autoimmune Markers in Addison's Disease Patients Compared to Healthy Controls.Journal of clinical medicine · 2025Article
- Increased risk of osteoporotic fractures and osteoporosis in patients with Addison's disease in Sweden: A nationwide population-based cohort study.Journal of internal medicine · 2025Article
- Non-Hypertensive Effects of Aldosterone.International journal of molecular sciences · 2025Review
- Impact of systemic treatments for advanced thyroid cancer on the adrenal cortex.European thyroid journal · 2024Article
- Hoarseness due to subcutaneous emphysema: a rare presentation of diverticular perforation.Journal of surgical case reports · 2024Article
- Serological Evidence and Self-reported Outcomes in Patients with Adrenal Insufficiency during the First Waves of COVID-19 in North-East Italy.Endocrine, metabolic & immune disorders drug targets · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAddison's disease (AD) is a rare disorder and among adult population in developed countries is most commonly caused by autoimmunity. In contrast, in children genetic causes are responsible for AD in the majority of patients. PURPOSE: This review describes epidemiology, pathogenesis, genetics, natural history, clinical manifestations, immunological markers and diagnostic strategies in patients with AD. Standard care treatments including the management of patients during pregnancy and adrenal crises consistent with the recent consensus statement of the European Consortium and the Endocrine Society Clinical Practice Guideline are described. In addition, emerging therapies designed to improve the quality of life and new strategies to modify the natural history of autoimmune AD are discussed.
conclusionsProgress in optimizing replacement therapy for patients with AD has allowed the patients to lead a normal life. However, continuous education of patients and health care professionals of ever-present danger of adrenal crisis is essential to save lives of patients with AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.