Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Cognitive functioning as a predictor of employment status in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.
Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review.BMC neurology · 2021Pooled it
- Clinical, Cognitive and Demographic Determinants of Work Participation in Multiple Sclerosis: A Multicenter Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Inhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function.Advances in pharmacology (San Diego, Calif.) · 2025Review
- Improvements in quality of life of patients with multiple sclerosis receiving alemtuzumab in clinical practice: the LEMVIDA study.Journal of patient-reported outcomes · 2024Article
- Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis.IBRO neuroscience reports · 2024Article
- Don't be late! Postponing cognitive decline and preventing early unemployment in people with multiple sclerosis: a study protocol.BMC neurology · 2024Article
- Don't be late! Timely identification of cognitive impairment in people with multiple sclerosis: a study protocol.BMC neurology · 2024Article
- Social determinants of health in multiple sclerosis.Nature reviews. Neurology · 2022Review
- Subjective cognitive impairment is related to work status in people with multiple sclerosis.IBRO neuroscience reports · 2022Article
- The TRACK-MS Test Battery: A Very Brief Tool to Track Multiple Sclerosis-Related Cognitive Impairment.Biomedicines · 2022Article
- Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis.Nanotheranostics · 2022Article
- The relationship between cognition, education, and employment in multiple sclerosis patients.Multiple sclerosis journal - experimental, translational and clinicalArticle
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Authors and funding
17 authors.
Funding
Abstract
backgroundCognitive functioning has been linked to employment outcomes in multiple sclerosis (MS) in cross-sectional studies. Longitudinal studies are however lacking and previous studies did not extensively examine executive functioning.
objectivesWe examined whether baseline cognitive functioning predicts a change in employment status after 2 years, while taking into account mood, fatigue and disability level.
methodsA total of 124 patients with relapsing-remitting MS (pwMS) and 60 healthy controls were included. They underwent neurological and neuropsychological examinations and completed online questionnaires. PwMS were divided into a stable and deteriorated employment status group (SES and DES), based on employment status 2 years after baseline. We first examined baseline differences between the SES and DES groups in cognitive functioning, mood, fatigue and disability level. A logistic regression analysis was performed, with change in employment status (SES/DES) as dependent variable.
resultsThe DES group included 22% pwMS. Group differences were found in complex attention, executive functioning, self-reported cognitive functioning, fatigue and physical disability. More physical disability (OR = 1.90, p = 0.01) and lower executive functioning (OR = 0.30, p = 0.03) were retained as independent predictors of DES (R
conclusionsBaseline physical disability and executive functioning, but none of the other variables, moderately predicted a deterioration in employment status 2 years later.
trial registrationThis observational study is registered under NL43098.008.12: 'Voorspellers van arbeidsparticipatie bij mensen met relapsing-remitting Multiple Sclerose'. This study is registered at the Dutch CCMO register (https://www.toetsingonline.nl).
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