Evidence map›Paper›PMID 31321550›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2019

Effect fingerprints of antipsychotic drugs on neural networks in vitro.

Philipp Görtz, Uwe Henning, Stephan Theiss, Christian Lange-Asschenfeldt

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Philipp GörtzDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Bergische Landstr. 2, 40629, Düsseldorf, Germany.
Uwe HenningDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Bergische Landstr. 2, 40629, Düsseldorf, Germany.
Stephan TheissInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Christian Lange-AsschenfeldtDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Bergische Landstr. 2, 40629, Düsseldorf, Germany. christian.lange-asschenfeldt@lvr.de.ORCID 0000-0001-9035-9372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the acute effect of typical (haloperidol) and atypical (aripiprazole, clozapine, olanzapine) antipsychotic drugs (APDs) on spontaneous electrophysiological activity of in vitro neuronal networks cultured on microelectrode arrays (MEAs). Network burst analysis revealed a "regularizing" effect of all APDs at therapeutic concentrations, i.e., an increase of network-wide temporal synchronization. At supratherapeutic concentrations, all APDs but olanzapine mediated a decrease of burst and spike rates, burst duration, number of spikes in bursts, and network synchrony. The rank order of potency of APDs was: haloperidol > aripiprazole > clozapine > olanzapine (no suppression). Disruption of network function was not due to enhanced cell death as assessed by trypan blue staining. APDs promoted distinct concentration-dependent alterations yielding acute effect fingerprints of the tested compounds. These effects were rather characteristic for individual compounds than distinctive for typical vs. atypical APDs. Thus, this dichotomy may be of value in distinguishing clinical features but has no apparent basis on the network or local circuitry level.

Indexed as

Action PotentialsAnimalsAnimals, NewbornAntipsychotic AgentsAripiprazoleCells, CulturedCerebral CortexClozapineDose-Response Relationship, DrugHaloperidolMiceMice, Inbred C57BLNerve NetAntipsychotic AgentsAripiprazoleClozapineHaloperidolAntipsychotic drugsMicroelectrode arrayNetwork burstsNeuronal network activityPrimary cortical culture

Identifiers

PMID31321550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.