Evidence map›Paper›PMID 31321545›Full record

ArticleMikrochimica acta2019

A SERS-based lateral flow assay for the stroke biomarker S100-β.

Ying Wang, Yajun Hou, Hanxia Li, Mingfeng Yang, Peng Zhao, Baoliang Sun

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Fluorescent hollow ZrOMikrochimica acta · 2021
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ying WangKey Lab of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Yajun HouKey Lab of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Hanxia LiKey Lab of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Mingfeng YangKey Lab of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Peng ZhaoRadiology College, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China. pengz9@163.com.
Baoliang SunKey Lab of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China. blsun88@163.com.

Funding

National Natural Science Foundation of China 81271275National Natural Science Foundation of China 81471212National Natural Science Foundation of China 81701179
6 · The paper itself

Abstract

A surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) is described for the quantitative analysis of the proteinic stroke biomarker S100-β that has to be detected at very low concentration levels. The Raman reporter 5,5'-dithiobis-2-nitrobenzoic acid (DTNB) on gold nanoparticles (GNPs) was employed as the SERS tags. They are shown to perform much better than bare GNPs in LF strips. The S100-β protein can be detected by this method with very low detection limits by monitoring the intensity of the characteristic Raman peak of the S100-β protein-conjugated GNPs at 1332 cm

Indexed as

Biosensing TechniquesBiological AssayBiomarkersGoldLimit of DetectionMetal NanoparticlesS100 Calcium Binding Protein beta SubunitSpectrum Analysis, RamanStrokeBiomarkersGoldS100 Calcium Binding Protein beta Subunit5,5′-Dithiobis-2-nitrobenzoic acidGNPsGold nanoparticles lateral flow stripsImmunosensorSERS nanotags

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.