Evidence map›Paper›PMID 31321458›Full record

ArticlePsychopharmacology2019

The use of reaction time distributions to study attention in male rats: the effects of atomoxetine and guanfacine.

Zach V Redding, Pooja Chawla, Karen E Sabol

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Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zach V ReddingDepartment of Psychology, The University of Mississippi, PO Box 1848, University, MS, 38677, USA.
Pooja ChawlaVirginia Commonwealth University Health System, Richmond, VA, USA.
Karen E SabolDepartment of Psychology, The University of Mississippi, PO Box 1848, University, MS, 38677, USA. ksabol@olemiss.edu.ORCID http://orcid.org/0000-0002-6883-7144
University of Mississippi · USVirginia Commonwealth University · US

Funding

University of Mississippi, Department of Psychology N/A
6 · The paper itself

Abstract

rationaleNorepinephrine (NE) is involved in the control of sustained attention. Studies of sustained attention in humans include measures of reaction time (RT) and RT variability (RTV). The present study tested the role of NE using components of the RT distribution in rats in a manner thought to be similar to human studies of RTV.

objectivesThis study tested the effects of increased synaptic NE (atomoxetine (ATX)) and α-2 receptor binding (guanfacine) on attentional lapses in rats.

methodsMale Sprague-Dawley rats (n = 20) were trained and tested in a two-choice RT task (2CRTT). Atomoxetine dose (saline, 0.1, 0.5, 1.0 mg/kg, i.p.), guanfacine dose (saline, 0.01, 0.1, 0.3 mg/kg, i.p.), and distractors were manipulated in three experiments. RT was divided into initiation time (IT) and movement time (MT). Analyses of distribution mode (peak) and deviation from the mode (skew) were then performed.

resultsATX and guanfacine had no effect on IT mode, reduced IT devmode, and increased MT mode. When distractors were introduced, ATX again improved devmode, but a lack of interaction between ATX and distractor indicated that ATX did not prevent distractor-induced impairments.

conclusionsIT devmode is a measure of distribution skew thought to reflect lapses of attention. The effects of ATX on IT devmode suggest that increased synaptic NE reduces attentional lapses. These findings are consistent with human reports of reduced RTV after ATX administration. The same pattern of results with guanfacine suggests that the effects of increased NE are due in part to binding at α-2 noradrenergic receptors.

Indexed as

Adrenergic alpha-2 Receptor AgonistsAdrenergic Uptake InhibitorsAnimalsAtomoxetine HydrochlorideAttentionDose-Response Relationship, DrugGuanfacineMaleNorepinephrineRatsRats, Sprague-DawleyReaction TimeAdrenergic alpha-2 Receptor AgonistsAdrenergic Uptake InhibitorsAtomoxetine HydrochlorideGuanfacineNorepinephrineADHDAtomoxetineDistractorsDistribution skewGuanfacineLapses of attentionNorepinephrineRatReaction time variabilityα-2 noradrenergic receptors

Identifiers

PMID31321458
OpenAlexW2960829727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.