ArticleRheumatology (Oxford, England)2020
Bariatric surgery and the incidence of rheumatoid arthritis - a Swedish Obese Subjects study.
Article in Rheumatology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01479452 (Effects of Bariatric Surgery in Swedish Obese Subjects), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Bariatric Surgery in Swedish Obese Subjects
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk.RMD open · 2024Pooled it
- Effect of bariatric and metabolic surgery on rheumatoid arthritis outcomes: A systematic review.PloS one · 2023Pooled it
- The association between bariatric surgery and incident rheumatoid arthritis.Rheumatology advances in practice · 2026Article
- [Impact of surgical treatment of morbid obesity on joint diseases].Problemy endokrinologii · 2023Review
- Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study.RMD open · 2022Article
- The associations between bariatric surgery and hip or knee arthroplasty, and hip or knee osteoarthritis: Propensity score-matched cohort studies.Osteoarthritis and cartilage open · 2022Article
- Long-term weight changes and risk of rheumatoid arthritis among women in a prospective cohort: a marginal structural model approach.Rheumatology (Oxford, England) · 2022Article
- Disease mechanisms in preclinical rheumatoid arthritis: A narrative review.Frontiers in medicine · 2022Review
- Adiponectin Associates with Rheumatoid Arthritis Risk in Overweight and Obesity Independently of Other Adipokines.Journal of clinical medicine · 2021Article
- Challenges and Opportunities of Targeted Behavioral Interventions for Groups at Risk for Developing Rheumatoid Arthritis.Healthcare (Basel, Switzerland) · 2021Review
- [The effect of obesity on disease activity of inflammatory rheumatic diseases].Zeitschrift fur Rheumatologie · 2021Review
- Adipocytokines in Untreated Newly Diagnosed Rheumatoid Arthritis: Association with Circulating Chemokines and Markers of Inflammation.Biomolecules · 2021Article
- Article
- Elevated adiponectin predicts the development of rheumatoid arthritis in subjects with obesity.Scandinavian journal of rheumatology · 2020Article
- The Impact of Obesity on Disease Activity and Treatment Response in Rheumatoid Arthritis.Current rheumatology reports · 2020Review
- The outcomes of bariatric surgery on rheumatoid arthritis disease activity: a prospective cohort study.Scientific reports · 2020Article
- Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality.Frontiers in immunology · 2020Review
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveThe aim of this study was to determine the effect of bariatric surgery on the incidence of RA in participants of the Swedish Obese Subjects (SOS) study.
methodsThe SOS is a longitudinal study aiming to assess the effect of bariatric surgery on mortality and obesity-related diseases. This report includes 2002 subjects with obesity who underwent bariatric surgery and 2034 matched controls; none of them had RA at baseline. Cases of incident RA were identified through the Swedish National Patient Register by searching for International Classification of Diseases codes. Both intention-to-treat analyses and per-protocol analyses are reported. In the per-protocol analysis, participants from the control group who underwent bariatric surgery later on during follow-up were censored at the time of surgery.
resultsDuring follow-up, 92 study participants developed RA. The median follow-up was 21 years (range 0-29). Bariatric surgery was neither associated with the incidence of RA in the intention-to-treat analysis [hazard ratio (HR) 0.92 (95% CI 0.59, 1.46), P = 0.74], nor in the per-protocol analysis [HR 0.86 (95% CI 0.54, 1.38), P = 0.53]. Weight change at the 2 year follow-up, expressed as the change in BMI compared with baseline, did not associate with the development of RA. Higher serum CRP levels and smoking associated with the future development of RA independent of other factors.
conclusionsWe did not detect any association between bariatric surgery and the incidence of RA in subjects affected by obesity followed up for up to 29 years. CLINICALTRIALS.GOV: (http://clinicaltrials.gov): NCT01479452.
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