ArticleJournal of the National Cancer Institute2019
Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.
Article in Journal of the National Cancer Institute, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04321187 (Influence of Radiotherapy on the Dynamics of Aging in Prostate Cancer Patients), which is not on this map. Cited by 148 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Radiotherapy on the Dynamics of Aging in Prostate Cancer Patients
Who cites it
148 citing papers in PubMed, 4 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Systematic review of associations between anxiety, depression, and functional/biological aging among cancer survivors.JNCI cancer spectrum · 2024Pooled it
- Blood-based biomarkers of frailty in solid tumors: a systematic review.Frontiers in public health · 2023Pooled it
- The prevalence of frailty among breast cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.CA: a cancer journal for clinicians · 2021Pooled it
- Trial
- Physical activity and mobility disability in older adult cancer survivors.JNCI cancer spectrum · 2025Trial
- DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer.Oncology nursing forum · 2024Trial
- Impact of Short-Term Creatine Supplementation on Muscular Performance among Breast Cancer Survivors.Nutrients · 2024Trial
- The effects of exercise and diet on oxidative stress and telomere length in breast cancer survivors.Breast cancer research and treatment · 2023Trial
- Effects of a DVD-delivered randomized controlled physical activity intervention on functional health in cancer survivors.BMC cancer · 2021Trial
- Evaluating the Test-Retest Reliability and Measurement Error of a Sit-Stand-Power Test in Individuals Treated for Cancer.Integrative cancer therapiesTrial
- Association of basal metabolic rate with mortality among cancer survivors: a cohort study emphasizing heterogeneity by gender and age.Annals of medicine · 2026Article
- Frailty and risk of common chronic diseases among cancer survivors: a prospective cohort study.Journal of cancer survivorship : research and practice · 2026Article
- Aging-related deficits accumulation and cancer-related outcomes in testicular and prostate cancer: Cross-sectional and longitudinal findings.Social science & medicine (1982) · 2026Article
- Frailty and associated factors in women aged 65 years and older with breast cancer: a cross-sectional study.BMC geriatrics · 2026Article
- The association of thigh myosteatosis with lower cognitive function in older cancer survivors.GeroScience · 2026Article
- Associations of Biological Aging With Perceived Stress in Patients With Head and Neck Cancer Undergoing Intensity Modulated Radiation Therapy: A Longitudinal Study.International journal of radiation oncology, biology, physics · 2026Article
- Article
- Changes in psoas muscle area in patients with colorectal cancer three years after surgery: a longitudinal approach.Langenbeck's archives of surgery · 2026Article
- Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
Observational data have shown that some cancer survivors develop chronic conditions like frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a greater burden than similarly aged individuals never diagnosed with cancer or exposed to systemic or targeted cancer therapies. In aggregate, cancer- and treatment-related physical, cognitive, and psychosocial late- and long-term morbidities experienced by cancer survivors are hypothesized to represent accelerated or accentuated aging trajectories. However, conceptual, measurement, and methodological challenges have constrained efforts to identify, predict, and mitigate aging-related consequences of cancer and cancer treatment. In July 2018, the National Cancer Institute convened basic, clinical, and translational science experts for a think tank titled "Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors." Through the resulting deliberations, several research and resource needs were identified, including longitudinal studies to examine aging trajectories that include detailed data from before, during, and after cancer treatment; mechanistic studies to elucidate the pathways that lead to the emergence of aging phenotypes in cancer survivors; long-term clinical surveillance to monitor survivors for late-emerging effects; and tools to integrate multiple data sources to inform understanding of how cancer and its therapies contribute to the aging process. Addressing these needs will help expand the evidence base and inform strategies to optimize healthy aging of cancer survivors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.