ArticlePlastic and reconstructive surgery. Global open2019
Soft-tissue Filler-associated Blindness: A Systematic Review of Case Reports and Case Series.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Autologous Fat Grafting Versus Facial Fillers in Facial Cosmesis: A Systematic review and Meta-analysis.Aesthetic plastic surgery · 2026Pooled it
- TFOS Lifestyle: Impact of cosmetics on the ocular surface.The ocular surface · 2023Pooled it
- Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature.Aesthetic plastic surgery · 2020Pooled it
- Cannula Gauge and Tissue Penetration Forces in the Temporal Region: A Biomechanical Basis for Injection Safety.Aesthetic plastic surgery · 2026Article
- Review
- When Genes Meet Gels: Computational Immunogenetics of Dermal Fillers and Stratified Risk of Immune and Fibrotic Reactions across Compositions and Genotypes.Aesthetic plastic surgery · 2026Article
- Transverse Facial Artery Morphometry Based on Head Dimensions and Palpable Anatomical Landmarks.Aesthetic surgery journal · 2026Article
- Management of Visual Loss Following Hyaluronic Acid Filler Injections: An Algorithm-based Approach.Plastic and reconstructive surgery. Global open · 2026Article
- Superficial temporal artery and branches in thai cadavers: anatomical variations, ethnic considerations, and filler injection safety.Scientific reports · 2025Article
- Permanent Vision Loss Due to Vascular Variation After Ear Hyaluronic Acid Injection: Two Case Reports and Literature Reviews.Aesthetic plastic surgery · 2025Review
- The Efficacy of Heparin and Nitroglycerin in Managing Vascular Embolism Complications from Polycaprolactone (PCL) Fillers: A Clinical Study.Aesthetic plastic surgery · 2025Article
- Complications of Nonsurgical Rhinoplasty with Hyaluronic Acid Injections: A Narrative Review.Aesthetic plastic surgery · 2025Review
- Vascular Labeling of Extracranial Head and Neck Vessels Using Silicone Dye Injection: An Effective Method for Cadaver-Based Facial Surgery Training.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2025Article
- Navigating the Labial Artery: A Safer Approach to Submucosal Lip Filler Techniques.Life (Basel, Switzerland) · 2025Article
- Exploring the venous supply of the face: An illustrated overview of contemporary literature.JPRAS open · 2025Review
- Aetiology, Diagnosis and Treatment of Arterial Occlusions of the Retina-A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Complications Associated with Facial Autologous Fat Grafting for Aesthetic Purposes: A Systematic Review of the Literature.Plastic and reconstructive surgery. Global open · 2024Article
- Commentary on: A Computed Tomographic Investigation of the Ophthalmic Artery Volume and its Relevance to Soft Tissue Filler Injection.Aesthetic surgery journal · 2023Article
- An illustrated anatomical approach to reducing vascular risk during facial soft tissue filler administration - a review.JPRAS open · 2023Review
- Thread Lifting of the Nose: Fully Comprehensive Approach to the Technique.Plastic and reconstructive surgery. Global open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the increase in the use of soft-tissue fillers worldwide, there has been a rise in the serious adverse events such as vascular compromise and blindness. This article aims to review the role of fillers in causing blindness and the association between hyaluronic acid (HA) filler and blindness.
methodsThe Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were used to report this review.
resultsA total of 190 cases of blindness due to soft-tissue fillers were identified, of which 90 (47%) cases were attributed to autologous fat alone, and 53 (28%) cases were caused by HA. The rest of the cases were attributed to collagen, calcium hydroxylapatite, and other fillers.
conclusionsAutologous fat was the most common filler associated with blindness despite HA fillers being the most commonly used across the globe. However, the blindness caused by other soft-tissue fillers like collagen and calcium hydroxylapatite was represented. It was also evident through the review that the treatment of HA-related blindness was likely to have better outcomes compared with other fillers due to hyaluronidase use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.