Evidence map›Paper›PMID 31320786›Full record

ArticleJournal of the Saudi Heart Association2019

Cognitive impairment associated with increased mortality rate in patients with heart failure: A systematic review and meta-analysis.

Jakrin Kewcharoen, Narut Prasitlumkum, Chanavuth Kanitsoraphan, Nattawat Charoenpoonsiri, Natthapon Angsubhakorn, Prapaipan Putthapiban, Pattara Rattanawong

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Article in Journal of the Saudi Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jakrin KewcharoenUniversity of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA.
Narut PrasitlumkumUniversity of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA.
Chanavuth KanitsoraphanUniversity of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA.
Nattawat CharoenpoonsiriDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Natthapon AngsubhakornUniversity of Minnesota Medical School, Department of Medicine, Minneapolis, MN, USA.
Prapaipan PutthapibanDepartment of Medicine, Einstein Medical Center, Philadelphia, PA, USA.
Pattara RattanawongUniversity of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent systematic review and meta-analysis showed that the prevalence of cognitive impairment was significantly increased in patients with heart failure (HF) when compared to the general population. However, the effect of cognitive impairment on cardiovascular outcome in this population is still unclear. We performed a systematic review and meta-analysis to assess whether cognitive impairment associated with worse outcome in patients with HF.

methodsWe comprehensively searched the databases of MEDLINE and EMBASE from inception to October 2018. Included studies were published cohort (prospective or retrospective) or randomized control trials that evaluate the effect of cognitive impairment mortality in HF patients. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate pooled hazard ratios (HR) and 95% confidence intervals (CI).

resultsEight studies were included in the analysis involving 3318 participants (951 participants had cognitive impairment). In a random-effects model, our analysis demonstrated that cognitive impairment significantly increased the risk of mortality in HF patients (pooled HR = 1.64, 95% CI = 1.42-1.88, I

conclusionOur systematic review and meta-analysis showed that the presence of cognitive impairment is strongly associated with an increased mortality risk in the HF population. Further research is needed to explore the pathophysiology of this association.

Indexed as

Cognitive dysfunctionHeart failureMortality

Identifiers

PMID31320786
PMCPMC6614112

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.