ArticleNature chemical biology2019
An excreted small molecule promotes C. elegans reproductive development and aging.
Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
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- Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.Biomolecules · 2025Review
- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Free long-chain fatty acids trigger early postembryonic development in starved Caenorhabditis elegans by suppressing mTORC1.PLoS biology · 2024Article
- TheApplied and environmental microbiology · 2024Article
- Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites.Nature chemical biology · 2024Article
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans.Nature communications · 2024Article
- C. elegans ageing is accelerated by a self-destructive reproductive programme.Nature communications · 2023Article
- Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.Genetics · 2023Article
- Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023Review
- AbioRxiv : the preprint server for biology · 2023Article
- Sex-specificity of the C. elegans metabolome.Nature communications · 2023Article
- The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions inProceedings. Biological sciences · 2022Article
- Article
- A male pheromone that improves the quality of the oogenic germline.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Optimization of metabolomic data processing using NOREVA.Nature protocols · 2022Review
- Combinatorial Assembly of Modular Glucosides via Carboxylesterases RegulatesJournal of the American Chemical Society · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Excreted small-molecule signals can bias developmental trajectories and physiology in diverse animal species. However, the chemical identity of these signals remains largely obscure. Here we report identification of an unusual N-acylated glutamine derivative, nacq#1, that accelerates reproductive development and shortens lifespan in Caenorhabditis elegans. Produced predominantly by C. elegans males, nacq#1 hastens onset of sexual maturity in hermaphrodites by promoting exit from the larval dauer diapause and by accelerating late larval development. Even at picomolar concentrations, nacq#1 shortens hermaphrodite lifespan, suggesting a trade-off between reproductive investment and longevity. Acceleration of development by nacq#1 requires chemosensation and is dependent on three homologs of vertebrate steroid hormone receptors. Unlike ascaroside pheromones, which are restricted to nematodes, fatty acylated amino acid derivatives similar to nacq#1 have been reported from humans and invertebrates, suggesting that related compounds may serve signaling functions throughout metazoa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.