ArticleScientific reports2019
Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Exploring the Metabolic Impact of FLASH Radiotherapy.Cancers · 2025Review
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- Study on the factors influencing lens opacity among medical radiation workers exposed to long-term low-dose ionizing radiation.Frontiers in medicine · 2025Article
- The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells.Current issues in molecular biology · 2024Article
- Effect of Ultrahigh Dose Rate on Biomolecular Radiation Damage.Radiation research · 2024Article
- The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation.Scientific reports · 2024Article
- Biological effects in normal human fibroblasts following chronic and acute irradiation with both low- and high-LET radiation.Frontiers in public health · 2024Article
- Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022Review
- Radiation dose-rate is a neglected critical parameter in dose-response of insects.Scientific reports · 2022Article
- Article
- An update on effects of ionizing radiation exposure on the eye.The British journal of radiology · 2020Review
- The Impact of Dose Rate on DNA Double-Strand Break Formation and Repair in Human Lymphocytes Exposed to Fast Neutron Irradiation.International journal of molecular sciences · 2019Article
- Review
- Inverse dose protraction effects of low-LET radiation: Evidence and significance.Mutation research. Reviews in mutation researchReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of dose rate on radiation cataractogenesis has yet to be extensively studied. One recent epidemiological investigation suggested that protracted radiation exposure increases radiation-induced cataract risk: cumulative doses of radiation mostly <100 mGy received by US radiologic technologists over 5 years were associated with an increased excess hazard ratio for cataract development. However, there are few mechanistic studies to support and explain such observations. Low-dose radiation-induced DNA damage in the epithelial cells of the eye lens (LECs) has been proposed as a possible contributor to cataract formation and thus visual impairment. Here, 53BP1 foci was used as a marker of DNA damage. Unexpectedly, the number of 53BP1 foci that persisted in the mouse lens samples after γ-radiation exposure increased with decreasing dose-rate at 4 and 24 h. The C57BL/6 mice were exposed to 0.5, 1 and 2 Gy ƴ-radiation at 0.063 and 0.3 Gy/min and also 0.5 Gy at 0.014 Gy/min. This contrasts the data we obtained for peripheral blood lymphocytes collected from the same animal groups, which showed the expected reduction of residual 53BP1 foci with reducing dose-rate. These findings highlight the likely importance of dose-rate in low-dose cataract formation and, furthermore, represent the first evidence that LECs process radiation damage differently to blood lymphocytes.
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