ArticleScientific reports2019
Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- Evolutionary History of the α-Carbonic Anhydrase Gene Family in the Phylum Arthropoda, With Comparisons to αCA in Chordates.Genome biology and evolution · 2026Article
- An acidic microenvironment produced by the V-type ATPase of Euprymna scolopes promotes specificity during Vibrio fischeri recruitment.Communications biology · 2024Article
- Stable isotopes in the shell organic matrix for (paleo)environmental reconstructions.Communications chemistry · 2024Article
- Article
- Unique evolution of foraminiferal calcification to survive global changes.Science advances · 2023Article
- Genome Study of α-, β-, and γ-Carbonic Anhydrases from the Thermophilic Microbiome of Marine Hydrothermal Vent Ecosystems.Biology · 2023Article
- The Mantle Transcriptome ofAnimals : an open access journal from MDPI · 2022Article
- Emerging trends in environmental and industrial applications of marine carbonic anhydrase: a review.Bioprocess and biosystems engineering · 2022Review
- Comparison of Carbonic Anhydrases for COInternational journal of molecular sciences · 2022Article
- Evolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins.Frontiers in endocrinology · 2021Article
- Comparative Transcriptomic and Expression Profiles Between the Foot Muscle and Mantle Tissues in the Giant Triton SnailFrontiers in physiology · 2021Article
- The calcitonin-like system is an ancient regulatory system of biomineralization.Scientific reports · 2020Article
- Dilution of Seawater Affects the CaFrontiers in physiology · 2020Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The α-carbonic anhydrases (α-CAs) are a large and ancient group of metazoan-specific enzymes. They generate bicarbonate from metabolic carbon dioxide and through calcium carbonate crystal formation play a key role in the regulation of mineralized structures. To better understand how α-CAs contribute to shell mineralization in the marine Mediterranean mussel (Mytilus galloprovincialis) we characterized them in the mantle. Phylogenetic analysis revealed that mollusc α-CA evolution was affected by lineage and species-specific events. Ten α-CAs were found in the Mediterranean mussel mantle and the most abundant form was named, MgNACR, as it grouped with oyster nacreins (NACR). Exposure of the Mediterranean mussel to reduced water salinity (18 vs 37 ppt), caused a significant reduction (p < 0.05) in mantle esterase activity and MgNACR transcript abundance (p < 0.05). Protonograms revealed multiple proteins in the mantle with α-CA hydratase activity and mapped to a protein with a similar size to that deduced for monomeric MgNACR. Our data indicate that MgNACR is a major α-CA enzyme in mantle and that by homology with oyster nacreins likely regulates mussel shell production. We propose that species-dependent α-CA evolution may contribute to explain the diversity of bivalve shell structures and their vulnerability to environmental changes.
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