Evidence map›Paper›PMID 31320684›Full record

ArticleScientific reports2019

Detailed Evaluation of Possible Ganglion Cell Loss in the Retina of Zucker Diabetic Fatty (ZDF) Rats.

Rozina I Hajdú, Lenke K Laurik, Klaudia Szabó, Bulcsú Dékány, Zsuzsanna Almási, Anna Énzsöly, Arnold Szabó, Tamás Radovits, Csaba Mátyás, Attila Oláh and 4 more

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Rozina I HajdúDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Lenke K LaurikDepartment of Ophthalmology, Semmelweis University, Budapest, Hungary.
Klaudia SzabóDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Bulcsú DékányDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Zsuzsanna AlmásiDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Anna ÉnzsölyDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Arnold SzabóDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Tamás RadovitsHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Csaba MátyásHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Attila OláhHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Ágoston SzélDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Gábor M SomfaiDepartment of Ophthalmology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0001-6329-442X
Csaba DávidDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Ákos LukátsDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary. lukatsakos@gmail.com.
Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A thinning of the inner retina is one of the earliest potential markers of neuroretinal damage in diabetic subjects. The histological background is uncertain; retinal ganglion cell (RGC) loss and changes in the structure or thickness of the inner plexiform layer (IPL) have been suspected. Studies conducted on animal models on RGC pathology gave contradictory results. Hereby we present RGC numbers, distribution patterns and IPL thickness from Zucker Diabetic Fatty (ZDF) rats. After labelling RGCs on retinal whole mounts, isodensity maps were constructed, RGC numbers and distribution patterns analysed using a custom-built algorithm, enabling point-by-point comparison. There was no change in staining characteristics of the antibodies and no significant difference in average RGC densities was found compared to controls. The distribution patterns were also comparable and no significant difference was found in IPL thickness and stratification or in the number of apoptotic cells in the ganglion cell layer (GCL). Our results provide a detailed evaluation of the inner retina and exclude major RGC loss in ZDF rats and suggest that other factors could serve as a potential explanation for inner retinal thinning in clinical studies. Our custom-built method could be adopted for the assessment of other animal or human retinas.

Indexed as

ApoptosisAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalMaleOptic NerveRatsRats, ZuckerRetinal Ganglion CellsBlood Glucose

Identifiers

PMID31320684
PMCPMC6639371
OpenAlexW2960347181

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.