Evidence map›Paper›PMID 31320680›Full record

ArticleScientific reports2019

Inflammatory Responses Reprogram T

Tim Hung-Po Chen, Manoj Arra, Gabriel Mbalaviele, Gaurav Swarnkar, Yousef Abu-Amer

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tim Hung-Po ChenDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Manoj ArraDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Gabriel MbalavieleBone and Mineral Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Gaurav SwarnkarDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Yousef Abu-AmerDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA. abuamery@wustl.edu.ORCID http://orcid.org/0000-0002-5890-5086
Washington University in St. Louis · USShriners Hospitals for Children - Erie · US

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7M
Regulatory Mechanisms of Implant-Induced OsteolysisR01AR049192 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2004 to 2019
$4.3M
Molecular Mechanisms Underlying Tak1 Function in OsteoclastsR01AR054326 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2008 to 2017
$3.3M
Mechanisms of Physiologic and Pathologic OsteoclastogenesisR01AR072623 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2018 to 2022
$1.7M
NLRP3 inflammasome Regulation of Bone ResorptionR01AR064755 · NIAMS · WASHINGTON UNIVERSITY · PI MBALAVIELE, GABRIEL · 2013 to 2017
$1.6M
Role of PARP1 in the Osteoclast LineageR01AR068972 · NIAMS · WASHINGTON UNIVERSITY · PI MBALAVIELE, GABRIEL · 2016 to 2020
$1.6M
NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR049192NIAMS NIH HHS R01 AR054326NIAMS NIH HHS R01 AR064755NIAMS NIH HHS R01 AR068972NIAMS NIH HHS R01 AR072623NIGMS NIH HHS T32 GM007200
6 · The paper itself

Abstract

Chronic inflammatory insults compromise immune cell responses and ultimately contribute to pathologic outcomes. Clinically, it has been suggested that bone debris and implant particles, such as polymethylmethacrylate (PMMA), which are persistently released following implant surgery evoke heightened immune, inflammatory, and osteolytic responses that contribute to implant failure. However, the precise mechanism underlying this pathologic response remains vague. T

Indexed as

AnimalsFemaleForkhead Transcription FactorsImmunity, InnateInflammationMaleMiceNeuropilin-1OsteoclastsOsteolysisPolymethyl MethacrylateTh17 CellsT-Lymphocytes, RegulatoryForkhead Transcription FactorsNeuropilin-1Polymethyl Methacrylate

Identifiers

PMID31320680
PMCPMC6639378
OpenAlexW2960737965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.