ArticleScientific reports2019
A whole-body Fast Field-Cycling scanner for clinical molecular imaging studies.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Open-Source Multinuclear Low-Field Preclinical MRI Scanner.NMR in biomedicine · 2026Article
- Understanding water properties in tumorous murine cells using field-cycling NMR relaxometry.Scientific reports · 2025Article
- Article
- Can magnetic resonance imaging (MRI) reduce lingual nerve injuries during mandibular third molar surgery? A scoping review.BMC oral health · 2025Article
- Field-cycling imaging yields repeatable brain RMagma (New York, N.Y.) · 2025Article
- Exploring the potential performance of 0.2 T low-field unshielded MRI scanner using deep learning techniques.Magma (New York, N.Y.) · 2025Article
- Paramagnetic salt and agarose recipes for phantoms with desired T1 and T2 values for low-field MRI.NMR in biomedicine · 2025Article
- MRI at low field: A review of software solutions for improving SNR.NMR in biomedicine · 2025Review
- Field cycling imaging to characterise breast cancer at low and ultra-low magnetic fields below 0.2 T.Communications medicine · 2024Article
- Markers of low field NMR relaxation features of tissues.Scientific reports · 2024Article
- AC Loss Measurement in NbIEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee · 2024Article
- A Review on the Use of Imaging Biomarkers in Oncology Clinical Trials: Quality Assurance Strategies for Technical Validation.Tomography (Ann Arbor, Mich.) · 2023Review
- Low-field MRI: A report on the 2022 ISMRM workshop.Magnetic resonance in medicine · 2023Review
- Tackling SNR at low-field: a review of hardware approaches for point-of-care systems.Magma (New York, N.Y.) · 2023Review
- In vivo quantitative MRI: TMagma (New York, N.Y.) · 2023Article
- An evolution of low-field strength MRI.Magma (New York, N.Y.) · 2023Review
- Low-field MRI: Clinical promise and challenges.Journal of magnetic resonance imaging : JMRI · 2023Review
- Article
- A dual-core NMR system for field-cycling singlet assisted diffusion NMR.Frontiers in chemistry · 2023Article
- Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke.Science advances · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fast Field-Cycling (FFC) is a well-established Nuclear Magnetic Resonance (NMR) technique that exploits varying magnetic fields to quantify molecular motion over a wide range of time scales, providing rich structural information from nanometres to micrometres, non-invasively. Previous work demonstrated great potential for FFC-NMR biomarkers in medical applications; our research group has now ported this technology to medical imaging by designing a whole-body FFC Magnetic Resonance Imaging (FFC-MRI) scanner capable of performing accurate measurements non-invasively over the entire body, using signals from water and fat protons. This is a unique tool to explore new biomarkers related to disease-induced tissue remodelling. Our approach required making radical changes in the design, construction and control of MRI hardware so that the magnetic field is switched within 12.5 ms to reach any field strength from 50 μT to 0.2 T, providing clinically useful images within minutes. Pilot studies demonstrated endogenous field-dependant contrast in biological tissues in good agreement with reference data from other imaging modalities, confirming that our system can perform multiscale structural imaging of biological tissues, from nanometres to micrometres. It is now possible to confirm ex vivo results obtained from previous clinical studies, offering applications in diagnosis, staging and monitoring treatment for cancer, stroke, osteoarthritis and oedema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.