Evidence map›Paper›PMID 31320650›Full record

ArticleNature communications2019

Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life.

Kyriel M Pineault, Jane Y Song, Kenneth M Kozloff, Daniel Lucas, Deneen M Wellik

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 114 citations in OpenAlex.

  1. Article
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  3. VEGF-D-induced intraosseous lymphangiogenesis drives site-specific heterotopic bone resorption.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  5. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  6. Review
  7. Stage-resolved geography of mouse skeletal stem cells.Journal of bone and mineral metabolism · 2026
    Review
  8. Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026
    Review
  9. Fibrous-layer resident Angptl7Cell research · 2026
    Article
  10. The Periosteum in Health and Disease.Current osteoporosis reports · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Creb5 controls its own expression and directly induces the joint interzone regulatory program.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kyriel M PineaultDepartment of Cell & Regenerative Biology, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Jane Y SongCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, 48109-2200, USA.ORCID http://orcid.org/0000-0002-2021-8184
Kenneth M KozloffDepartment of Orthopedic Surgery, University of Michigan, Ann Arbor, MI, 48109-2200, USA.ORCID http://orcid.org/0000-0002-1108-7258
Daniel LucasDivision of Experimental Hematology and Cancer Research, Cincinnati Children's Medical Center, Cincinnati, OH, 45229-2842, USA.ORCID http://orcid.org/0000-0002-0147-5425
Deneen M WellikDepartment of Cell & Regenerative Biology, University of Wisconsin-Madison, Madison, WI, 53705, USA. wellik@wisc.edu.ORCID http://orcid.org/0000-0003-4078-8560
University of Michigan · USUniversity of Wisconsin–Madison · USCincinnati Children's Hospital Medical Center · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
TRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9M
Role of Hox Genes in Integration of the Musculoskeletal System in Development R01AR061402 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI WELLIK, DENEEN M · 2011 to 2021
$3.3M
NCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR061402NICHD NIH HHS T32 HD007505NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the embryonic patterning transcription factor, Hoxa11, in adult skeletal progenitor-enriched MSCs. Here, using a newly generated Hoxa11-CreER

Indexed as

AdipocytesAnimalsBone and BonesBone RegenerationChondrocytesHomeodomain ProteinsMesenchymal Stem CellsMiceMice, Inbred C57BLMice, TransgenicModels, AnimalOsteoblastsReceptors, LeptinSp7 Transcription FactorHomeodomain ProteinsHoxa11 protein, mouseleptin receptor, mouseReceptors, LeptinSp7 protein, mouseSp7 Transcription FactorTlx1 protein, mouse

Identifiers

PMID31320650
PMCPMC6639390
OpenAlexW2958601838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.