ArticleNature communications2019
Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Staphylococcus aureus-induced degeneration of nociceptive neurons in Caenorhabditis elegans.BMC biology · 2025Article
- A multilayered gap junction network is essential for social decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Serotonergic Signaling GovernseNeuro · 2025Article
- Article
- Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.iScience · 2025Article
- Nucleic acid aptamers protect against lead (Pb(II)) toxicity.New biotechnology · 2024Article
- Meloidogyne incognita genes involved in the repellent behavior in response to ascr#9.Scientific reports · 2024Article
- Nucleic Acid Aptamers Protect Against Lead (Pb(II)) Toxicity.bioRxiv : the preprint server for biology · 2024Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.Genetics · 2023Article
- Two-photon fluorescence imaging and specifically biosensing of norepinephrine on a 100-ms timescale.Nature communications · 2023Article
- Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023Review
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- Article
- Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.eLife · 2022Article
- Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.Communications biology · 2021Article
- Neuronal control of maternal provisioning in response to social cues.Science advances · 2021Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- An Untargeted Approach for Revealing Electrophilic Metabolites.ACS chemical biology · 2020Article
- Photoaffinity probes for nematode pheromone receptor identification.Organic & biomolecular chemistry · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in cell-to-cell signaling, as biogenic amines are not normally recruited for communication between separate individuals. Here, we show that in the nematode C. elegans, a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter, octopamine. Neuronal ablation, cell-specific genetic rescue, and calcium imaging show that tyra-2 expression in the nociceptive neuron, ASH, is necessary and sufficient to induce osas#9 avoidance. Ectopic expression in the AWA neuron, which is generally associated with attractive responses, reverses the response to osas#9, resulting in attraction instead of avoidance behavior, confirming that TYRA-2 partakes in the sensing of osas#9. The TYRA-2/osas#9 signaling system represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor.
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Registered trials
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