Evidence map›Paper›PMID 31320588›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

An essential bifunctional enzyme in

Hua Wang, Alexander A Fedorov, Elena V Fedorov, Debbie M Hunt, Angela Rodgers, Holly L Douglas, Acely Garza-Garcia, Jeffrey B Bonanno, Steven C Almo, Luiz Pedro Sório de Carvalho

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 68 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
  5. A cloaked glutamate decarboxylase sustains the GABA shunt inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
  7. Protein Architecture and Composition in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. CLYBL averts vitamin BNature chemical biology · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Itaconate mechanism of action and dissimilation inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Hua WangMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0001-5780-9685
Alexander A FedorovDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Elena V FedorovDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Debbie M HuntMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Angela RodgersMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Holly L DouglasMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Acely Garza-GarciaMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Jeffrey B BonannoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Steven C AlmoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Luiz Pedro Sório de CarvalhoMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom; luiz.carvalho@crick.ac.uk.ORCID 0000-0003-2875-4552
Albert Einstein College of Medicine · USThe Francis Crick Institute · GB

Funding

Protein/Structure CoreP01GM118303 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GERLT, JOHN A · 2016 to 2020
$11.4M
An integrated X-ray data collection systemS10OD020068 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C. · 2015 to 2015
$600k
Cancer Research UK FC001029Cancer Research UK FC001060Medical Research Council FC001029Medical Research Council FC001060Medical Research Council MC_U117533887NIGMS NIH HHS P01 GM118303NIH HHS S10 OD020068Wellcome Trust 104785/B/14/ZWellcome Trust FC001029Wellcome Trust FC001060
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AerosolsAnimalsBiocatalysisLeucineLigandsLyasesMalatesMice, Inbred C57BLMycobacterium tuberculosisPhylogenyRecombinant ProteinsStereoisomerismSuccinatesTuberculosisAerosolsitaconic acidLeucineLigandsLyasesMalatesmalic acidRecombinant ProteinsSuccinatescarbon–carbon bond lyaseenzyme functionitaconate catabolismleucine catabolismMycobacterium tuberculosis

Identifiers

PMID31320588
PMCPMC6689899
OpenAlexW2961847442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.