ArticleScience (New York, N.Y.)2019
Cortical layer-specific critical dynamics triggering perception.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 387 papers.
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Who cites it
387 citing papers in PubMed.
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- Highly attenuated dendritic propagation of isolated synaptic potentials in vivo.Science advances · 2026Article
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo.Nature methods · 2026Article
- Probing inter-areal computations with a two-photon holographic mesoscope.Nature neuroscience · 2026Article
- Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.Nature communications · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Convergence of schizophrenia risk genes on CALN1 disrupts human forebrain development and drives core psychotic behaviors including hallucination-like perception.BMC medicine · 2026Article
- Article
- Neuronal ensembles in cortical function and disease.Physiological reviews · 2026Review
- Using Virtual Patients to Predict Perceptual Outcomes for Optogenetic Sight Recovery Technologies.Research square · 2026Article
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive optogenetic induction of cardiac arrhythmias alters systemic hemodynamics in mice.Science advances · 2026Article
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
327 more citing papers are in PubMed but not listed here.
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16 authors.
Funding
Abstract
Perceptual experiences may arise from neuronal activity patterns in mammalian neocortex. We probed mouse neocortex during visual discrimination using a red-shifted channelrhodopsin (ChRmine, discovered through structure-guided genome mining) alongside multiplexed multiphoton-holography (MultiSLM), achieving control of individually specified neurons spanning large cortical volumes with millisecond precision. Stimulating a critical number of stimulus-orientation-selective neurons drove widespread recruitment of functionally related neurons, a process enhanced by (but not requiring) orientation-discrimination task learning. Optogenetic targeting of orientation-selective ensembles elicited correct behavioral discrimination. Cortical layer-specific dynamics were apparent, as emergent neuronal activity asymmetrically propagated from layer 2/3 to layer 5, and smaller layer 5 ensembles were as effective as larger layer 2/3 ensembles in eliciting orientation discrimination behavior. Population dynamics emerging after optogenetic stimulation both correctly predicted behavior and resembled natural internal representations of visual stimuli at cellular resolution over volumes of cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.