Evidence map›Paper›PMID 31320522›Full record

ArticleScience (New York, N.Y.)2019

Making precision medicine personal for cystic fibrosis.

Candela Manfredi, Janice M Tindall, Jeong S Hong, Eric J Sorscher

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Molecular therapy. Nucleic acids · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Genomic newborn screening for rare diseases.Nature reviews. Genetics · 2023
    Review
  10. Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  11. A Novel 7ACS medicinal chemistry letters · 2023
    Article
  12. Review
  13. Article
  14. Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Global assessment of the integrated stress response in CF patient-derived airway and intestinal tissues.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020
    Article
  20. Immunomodulation in Cystic Fibrosis: Why and How?International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Candela ManfrediEmory University School of Medicine, Atlanta, GA, USA.
Janice M TindallUniversity of Alabama at Birmingham, Birmingham, AL USA.
Jeong S HongEmory University School of Medicine, Atlanta, GA, USA.
Eric J SorscherEmory University School of Medicine, Atlanta, GA, USA. esorscher@emory.edu.

Funding

Ribosomal perturbation as a mechanism to prevent misfolding of CFTRR01HL136414 · NHLBI · EMORY UNIVERSITY · PI HARTMAN, JOHN L, SORSCHER, ERIC J · 2018 to 2025
$4.5M
Rare mutations in Cystic Fibrosis: Overcoming barriers to personalized medicineR01HL139876 · NHLBI · EMORY UNIVERSITY · PI DAVIS, BRIAN R., SORSCHER, ERIC J · 2018 to 2022
$3.8M
NHLBI NIH HHS R01 HL136414NHLBI NIH HHS R01 HL139876
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorHumansMutationPrecision MedicineCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID31320522
PMCPMC7060931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.