Evidence map›Paper›PMID 31320495›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity.

Nicholas B Miner, Tamara J Phillips, Aaron Janowsky

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Pediatric methamphetamine poisoning: Case report of a one-year-old child.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025
    Article
  5. Article
  6. Review
  7. Maternal use of methamphetamine alters cardiovascular function in the adult offspring.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2023
    Review
  8. Confirmation of a CausalFrontiers in psychiatry · 2021
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nicholas B MinerResearch Service, VA Portland Health Care System, Portland, Oregon (N.B.M., T.J.P., A.J.); and Departments of Behavioral Neuroscience (N.B.M., T.J.P., A.J.) and Psychiatry (A.J.), and The Methamphetamine Abuse Research Center (T.J.P., A.J.), Oregon Health & Science University, Portland, Oregon.
Tamara J PhillipsResearch Service, VA Portland Health Care System, Portland, Oregon (N.B.M., T.J.P., A.J.); and Departments of Behavioral Neuroscience (N.B.M., T.J.P., A.J.) and Psychiatry (A.J.), and The Methamphetamine Abuse Research Center (T.J.P., A.J.), Oregon Health & Science University, Portland, Oregon.
Aaron JanowskyResearch Service, VA Portland Health Care System, Portland, Oregon (N.B.M., T.J.P., A.J.); and Departments of Behavioral Neuroscience (N.B.M., T.J.P., A.J.) and Psychiatry (A.J.), and The Methamphetamine Abuse Research Center (T.J.P., A.J.), Oregon Health & Science University, Portland, Oregon janowsky@ohsu.edu.
VA Portland Health Care System · USOregon Health & Science University · US

Funding

Traditional Service Core [Translational Service Core (TSC)]P50DA018165 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2006 to 2016
$13.0M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
Genetic Risk for Methamphetamine AbuseU01DA041579 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2016 to 2020
$2.1M
Genetic Factors Underlying Risk for Methamphetamine Intake and Associated TraitsR01DA046081 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2018 to 2022
$1.7M
Opioid Sensitive GABA inputs to the Ventral MidbrainR01DA034388 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 2012 to 2016
$967k
Genetic basis of methamphetamine intakeI01BX002106 · VA · PORTLAND VA MEDICAL CENTER · PI PHILLIPS, TAMARA J. · 2014 to 2022
–
BLRD VA I01 BX002106BLRD VA I01 BX002758BLRD VA IK6 BX006342NIDA NIH HHS P50 DA018165NIDA NIH HHS R01 DA034388NIDA NIH HHS R01 DA046081NIDA NIH HHS T32 DA007262NIDA NIH HHS U01 DA041579
6 · The paper itself

Abstract

Methamphetamine (MA) impairs vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function and expression, increasing intracellular DA levels that lead to neurotoxicity. The trace amine-associated receptor 1 (TAAR1) is activated by MA, but when the receptor is not activated, MA-induced neurotoxicity is increased. To investigate interactions among TAAR1, VMAT2, and DAT, transporter function and expression were measured in transgenic

Indexed as

AnimalsCentral Nervous System StimulantsDopamine Plasma Membrane Transport ProteinsFemaleMaleMethamphetamineMiceMice, Inbred C57BLNeurotoxicity SyndromesProtein BindingReceptors, G-Protein-CoupledSynaptosomesTrace Amine-Associated ReceptorsVesicular Monoamine Transport ProteinsCentral Nervous System StimulantsDopamine Plasma Membrane Transport ProteinsMethamphetamineReceptors, G-Protein-CoupledSlc18a1 protein, mouseTrace Amine-Associated ReceptorsVesicular Monoamine Transport Proteins

Identifiers

PMID31320495
PMCPMC6750185
OpenAlexW2963017414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.