Evidence map›Paper›PMID 31320477›Full record

ArticleThe Journal of biological chemistry2019

Water molecules mediate zinc mobility in the bacterial zinc diffusion channel ZIPB.

Sayan Gupta, Chengfeng Merriman, Christopher J Petzold, Corie Y Ralston, Dax Fu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Direct evidence of acid-driven protein desolvation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Metalation and activation of ZnBiophysics reviews · 2023
    Review
  7. Article
  8. Article
  9. The Solvation of theInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. Transcription factors and transporters in zinc homeostasis: lessons learned from fungi.Critical reviews in biochemistry and molecular biology · 2020
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sayan GuptaBerkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720.
Chengfeng MerrimanDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
Christopher J PetzoldBiological Systems Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720; Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720.
Corie Y RalstonBerkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720.
Dax FuDepartment of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205. Electronic address: dfu3@jhmi.edu.
Lawrence Berkeley National Laboratory · USJohns Hopkins University · US

Funding

Development of high-dose time-resolved x-ray footprinting technologies to enable the next level of structural analysis for challenging biological problemsR01GM126218 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI RALSTON, CORIE Y · 2018 to 2025
$3.4M
Molecular mechanism of intestinal zinc uptakeR01DK108599 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FU, DAX · 2015 to 2018
$1.7M
NIDDK NIH HHS R01 DK108599NIGMS NIH HHS R01 GM126218
6 · The paper itself

Abstract

Regulated ion diffusion across biological membranes is vital for cell function. In a nanoscale ion channel, the active role of discrete water molecules in modulating hydrodynamic behaviors of individual ions is poorly understood because of the technical challenge of tracking water molecules through the channel. Here we report the results of a hydroxyl radical footprinting analysis of the zinc-selective channel ZIPB from the Gram-negative bacterium,

Indexed as

Biological TransportBordetella bronchisepticaCation Transport ProteinsDiffusionWaterZincCation Transport ProteinsWaterZincmechanismmembrane proteinmetal ion–protein interactionprotein conformationtransporttransport metalwaterX-ray footprintingzinc

Identifiers

PMID31320477
PMCPMC6737223
OpenAlexW2963310552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.