ReviewPediatrics2019
Cognitive and Behavioral Impact on Children Exposed to Opioids During Pregnancy.
Review in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Non-pharmacological care for opioid withdrawal in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Sex and female empowerment (SAFE): A randomized trial comparing sexual health interventions for women in treatment for opioid use disorder.Drug and alcohol dependence · 2021Trial
- Trust but verify…the importance of multimethod and biomarker assessments of prenatal substance exposures.Pediatric research · 2026Article
- Teacher-reported kindergarten development among children exposed to prescription opioids during pregnancy.PloS one · 2026Article
- From morphine to buprenorphine - Modeling opioid use disorder and its treatment during pregnancy: Effects on maternal care and offspring neurodevelopment in a translational rodent model.Pharmacology, biochemistry, and behavior · 2025Article
- Prenatal opioid exposure and maternal HCV infection impair microglia development and function: A patient-specific in vitro model.Brain, behavior, and immunity · 2025Article
- Engagement With Recommended Developmental Follow-up and Supports Among Infants With Intrauterine Opioid Exposure.Journal of developmental and behavioral pediatrics : JDBP · 2025Article
- Disrupted maternal behavior in morphine-dependent pregnant rats and anhedonia in their offspring.Neuropharmacology · 2025Article
- Article
- Disrupted Maternal Behavior in Morphine-Dependent Pregnant Rats and Anhedonia in their Offspring.bioRxiv : the preprint server for biology · 2024Article
- Neurobehavioral disorders among children born to mothers exposed to illicit substances during pregnancy.BMC medicine · 2024Article
- Impact of a qualitative assessment approach for neonatal abstinence syndrome management: experience of a European reference center.Italian journal of pediatrics · 2024Article
- Reviewing the Impact of Maternal Opioid Use Disorder on Fetal Development and Long-Term Pediatric Health Outcomes.Cureus · 2024Review
- Neurobehavioral outcomes of infants exposed to buprenorphine-naloxone compared with naltrexone during pregnancy.Early human development · 2024Article
- Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Prenatal Exposure to Opioids and Neurodevelopmental Disorders in Children: A Bayesian Mediation Analysis.American journal of epidemiology · 2024Article
- Recruitment and retention strategies to promote research engagement among caregivers and their children: A scoping review.Journal of clinical and translational science · 2024Article
- Project SCOPE: a National Training Initiative to improve capacity of providers to support children impacted by prenatal opioid exposure using the ECHO model™.Frontiers in public health · 2024Article
- Article
- DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study.AJNR. American journal of neuroradiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 1 country.
Funding
Abstract
The developmental impact of opioid use during pregnancy is a subject of ongoing debate. Short-term neonatal outcomes, such as lower birth weight and neonatal abstinence syndrome, are the most well-recognized outcomes. However, knowledge gaps exist regarding longer-term neurocognitive and mental health outcomes. In this article, we summarize an expert panel discussion that was held in April 2018 by the Substance Abuse and Mental Health Services Administration and attended by national experts in the field of perinatal opioid exposure and its impact on child development. Despite the challenges with research in this area, there is emerging literature revealing an association between neonates exposed to opioids in utero and longer-term adverse neurocognitive, behavioral, and developmental outcomes. Although adverse sequalae may not be apparent in the neonatal period, they may become more salient as children develop and reach preschool and school age. Multiple variables (genetic, environmental, and biological) result in a highly complex picture. The next steps and strategies to support families impacted by opioid use disorder are explored. Model programs are also considered, including integrated care for the child and mother, parenting supports, and augmentations to home visiting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.