Evidence map›Paper›PMID 31320450›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance.

L Passamonti, K A Tsvetanov, P S Jones, W R Bevan-Jones, R Arnold, R J Borchert, E Mak, L Su, J T O'Brien, J B Rowe

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 1 synthesis or guideline pooled it, 220 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Article
  9. Elevation in network dynamics amplifies amyloid-dependent tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  10. Review
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Molecular and Clinical Considerations for Anesthesia in the Aging Brain.International journal of molecular sciences · 2025
    Review
  19. Review
  20. Review

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

L PassamontiIstituto di Bioimmagini e Fisiologia Molecolare (IBFM), Consiglio Nazionale delle Ricerche (CNR), 20090, Milano, Italy, lp337@medschl.cam.ac.uk.ORCID 0000-0002-7937-0615
K A TsvetanovDepartments of Clinical Neurosciences.ORCID 0000-0002-3178-6363
P S JonesDepartments of Clinical Neurosciences.
W R Bevan-JonesPsychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and.
R ArnoldDepartments of Clinical Neurosciences.
R J BorchertDepartments of Clinical Neurosciences.
E MakPsychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and.
L SuPsychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and.
J T O'BrienPsychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and.
J B RoweDepartments of Clinical Neurosciences.ORCID 0000-0001-7216-8679
Center for Neurosciences · USUniversity of Cambridge · GBInstitute of Molecular Bioimaging and Physiology · ITMRC Cognition and Brain Sciences Unit · GB

Funding

Medical Research Council MR/P01271X/1Medical Research Council RG91365/SUAG/004Wellcome TrustWellcome Trust 103838
6 · The paper itself

Abstract

Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer's disease (AD). We tested the relationship between neuroinflammation and the disruption of functional connectivity in large-scale networks, and their joint influence on cognitive impairment. We combined [

Indexed as

CognitionConnectomeAgedAged, 80 and overAlzheimer DiseaseAmidesCerebral CortexFemaleHippocampusHumansInflammationIsoquinolinesMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyAmidesIsoquinolines(R)-(11C)1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamideRadiopharmaceuticals[11C]PK11195Alzheimer's diseasefunctional connectivityindependent component analysisneuroinflammationPET

Identifiers

PMID31320450
PMCPMC6733539
OpenAlexW2962369126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.