Evidence map›Paper›PMID 31320448›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Diverse Mechanisms Lead to Common Dysfunction of Striatal Cholinergic Interneurons in Distinct Genetic Mouse Models of Dystonia.

Karen L Eskow Jaunarajs, Mariangela Scarduzio, Michelle E Ehrlich, Lori L McMahon, David G Standaert

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  4. A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  16. Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2021
    Article
  17. Article
  18. Selective Manipulation of G-Protein γThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Karen L Eskow JaunarajsDepartment of Neurology, Center for Neurodegeneration and Experimental Therapeutics.
Mariangela ScarduzioDepartment of Neurology, Center for Neurodegeneration and Experimental Therapeutics.
Michelle E EhrlichDepartment of Neurology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York 10029.
Lori L McMahonDepartment of Neurology, Center for Neurodegeneration and Experimental Therapeutics, dstandaert@uabmc.edu mcmahon@uab.edu.ORCID 0000-0003-1104-6584
David G StandaertDepartment of Neurology, Center for Neurodegeneration and Experimental Therapeutics, dstandaert@uabmc.edu mcmahon@uab.edu.ORCID 0000-0003-2921-8348
Center for Neuro-Oncology · USIcahn School of Medicine at Mount Sinai · USLeonard J. Chabert Medical Center · USUniversity of Alabama at Birmingham · US

Funding

Torsin Function in DrosiphilaP01NS037409 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI OZELIUS, LAURIE J. · 1999 to 2007
$8.5M
TorsinA as a key link in receptor-mediated signalingP01NS087997 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, OZELIUS, LAURIE J. · 2015 to 2019
$6.4M
Dopamine D1 Receptor in mouse models of primary dystoniaR01NS081282 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, MARTEMYANOV, KIRILL A. · 2013 to 2017
$2.5M
NINDS NIH HHS P01 NS037409NINDS NIH HHS P01 NS087997NINDS NIH HHS R01 NS081282
6 · The paper itself

Abstract

Clinical and experimental data indicate striatal cholinergic dysfunction in dystonia, a movement disorder typically resulting in twisted postures via abnormal muscle contraction. Three forms of isolated human dystonia result from mutations in the

Indexed as

AcetylcholineAnimalsbeta-ArrestinsCholinergic NeuronsCorpus StriatumDNA-Binding ProteinsDystoniaExtracellular SpaceFemaleGlucosamine 6-Phosphate N-AcetyltransferaseInterneuronsMaleMiceMice, Inbred C57BLMolecular ChaperonesReceptors, Dopamine D2Acetylcholinebeta-ArrestinsDNA-Binding ProteinsDyt1 protein, mouseGlucosamine 6-Phosphate N-AcetyltransferaseGnpnat1 protein, mouseMolecular ChaperonesReceptors, Dopamine D2Receptors, MuscarinicTHAP1 protein, mouseacetylcholinecholinergic interneurondystoniaG-protein-coupled receptorsmicestriatum

Identifiers

PMID31320448
PMCPMC6733543
OpenAlexW2962093200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.