Evidence map›Paper›PMID 31320149›Full record

ArticleUltrasound in medicine & biology2019

Resolution of Murine Toxic Hepatic Injury Quantified With Ultrasound Entropy Metrics.

Jon N Marsh, Kevin M Korenblat, Ta-Chiang Liu, John E McCarthy, Samuel A Wickline

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jon N MarshDepartment of Immunology & Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.
Kevin M KorenblatDepartment of Internal Medicine-Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ta-Chiang LiuDepartment of Anatomic & Molecular Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.
John E McCarthyDepartment of Mathematics and Statistics, Washington University, St. Louis, Missouri, USA.
Samuel A WicklineUniversity of South Florida Health Heart Institute, Morsani School of Medicine, Tampa, Florida, USA. Electronic address: wicklines@aol.com.

Funding

METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
Prevention and Treatment of Acute Kidney InjuryR01DK102691 · NIDDK · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2015 to 2018
$2.0M
Inhibition of NF-kB with siRNA/Peptide Nanoparticles for Arthritis TreatmentR01AR067491 · NIAMS · WASHINGTON UNIVERSITY · PI PHAM, CHRISTINE T., WICKLINE, SAMUEL A · 2015 to 2019
$1.8M
THERAPY NANOPARTICLES FOR MODULATION OF INFLAMMATION IN NEUROMUSCULAR DISEASER01AR056223 · NIAMS · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2009 to 2013
$1.6M
REAL TIME ULTRASOUND ENTROPY-BASED QUANTIFICATION OF FIBROFATTY LIVER DISEASER21EB019569 · NIBIB · WASHINGTON UNIVERSITY · PI MCCARTHY, JOHN E., WICKLINE, SAMUEL A · 2015 to 2016
$419k
NHLBI NIH HHS R01 HL073646NIAMS NIH HHS R01 AR056223NIAMS NIH HHS R01 AR067491NIBIB NIH HHS R21 EB019569NIDDK NIH HHS R01 DK102691
6 · The paper itself

Abstract

Image-based classification of liver disease generally lacks specificity for distinguishing between acute, resolvable injury and chronic irreversible injury. We propose that ultrasound radiofrequency data acquired in vivo from livers subjected to toxic drug injury can be analyzed with information theoretic detectors to derive entropy metrics, which classify a statistical distribution of pathologic scatterers that dissipate over time as livers heal. Here we exposed 38 C57BL/6 mice to carbon tetrachloride to cause liver damage, and imaged livers in vivo 1, 4, 8, 12 and 18 d after exposure with a broadband 15-MHz probe. Selected entropy metrics manifested monotonic recovery to normal values over time as livers healed, and were correlated directly with progressive restoration of liver architecture by histologic assessment (r

Indexed as

AnimalsCarbon TetrachlorideChemical and Drug Induced Liver InjuryDisease Models, AnimalEntropyImage Processing, Computer-AssistedLiverMiceMice, Inbred C57BLUltrasonographyCarbon TetrachlorideCarbon tetrachlorideEntropyLiver recoveryLiver toxicityQuantitative ultrasoundTissue characterizationUltrasound

Identifiers

PMID31320149
PMCPMC6718339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.