Evidence map›Paper›PMID 31319932›Full record

ArticleVaccine2019

Maternal immunization in Malawi: A mixed methods study of community perceptions, programmatic considerations, and recommendations for future planning.

Jessica A Fleming, Alister Munthali, Bagrey Ngwira, John Kadzandira, Monica Jamili-Phiri, Justin R Ortiz, Philipp Lambach, Joachim Hombach, Kathleen M Neuzil, Maria Stepanchak and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Observational
  6. Article
  7. Article
  8. Article
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  10. Review
  11. Review
  12. The Operational Feasibility of Vaccination Programs Targeting Influenza Risk Groups in the World Health Organization (WHO) African and South-East Asian Regions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  13. National routine adult immunisation programmes among World Health Organization Member States: an assessment of health systems to deploy COVID-19 vaccines.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Jessica A FlemingCenter for Vaccine Innovation and Access, PATH, 2201 Westlake Ave, Suite 200, Seattle, WA 98121, USA. Electronic address: jfleming@path.org.
Alister MunthaliThe Centre for Social Research, University of Malawi, PO Box 280, Zomba, Malawi. Electronic address: amunthali@cc.ac.mw.
Bagrey NgwiraMalawi Polytechnic, Private Bag 303, Chichiri, Blantyre 3, Malawi.
John KadzandiraThe Centre for Social Research, University of Malawi, PO Box 280, Zomba, Malawi.
Monica Jamili-PhiriThe Centre for Social Research, University of Malawi, PO Box 280, Zomba, Malawi. Electronic address: mjamali@cc.ac.mw.
Justin R OrtizInitiative for Vaccine Research, World Health Organization, Appia 20, 1211, Geneva 27, Switzerland. Electronic address: JOrtiz@som.umaryland.edu.
Philipp LambachInitiative for Vaccine Research, World Health Organization, Appia 20, 1211, Geneva 27, Switzerland. Electronic address: lambachp@who.int.
Joachim HombachInitiative for Vaccine Research, World Health Organization, Appia 20, 1211, Geneva 27, Switzerland. Electronic address: hombachj@who.int.
Kathleen M NeuzilCenter for Vaccine Innovation and Access, PATH, 2201 Westlake Ave, Suite 200, Seattle, WA 98121, USA. Electronic address: kneuzil@som.umaryland.edu.
Maria StepanchakGlobal Alliance to Prevent Prematurity and Stillbirth, 19009 33rd Ave W #200, Lynnwood, WA 98036, USA. Electronic address: Maria.Stepanchak@seattlechildrens.org.
Niranjan BhatCenter for Vaccine Innovation and Access, PATH, 2201 Westlake Ave, Suite 200, Seattle, WA 98121, USA. Electronic address: nbhat@path.org.
Program for Appropriate Technology in Health · USUniversity of Malawi · MWWorld Health Organization · CHGlobal Alliance to Prevent Prematurity and Stillbirth · USMuseum of Malawi · MW

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundSafe, effective vaccines are given to pregnant women to protect their infants and/or themselves against certain infectious agents; however, apart from tetanus vaccination, maternal immunization in low- and middle-income countries (LMICs) remains low. Tetanus toxoid vaccine is integrated into antenatal care services in Malawi with high coverage and provides an opportunity to identify factors that facilitate successful immunization delivery to pregnant women in LMICs.

methodsPATH and the University of Malawi's Centre for Social Research conducted a mixed-methods study in 2015 to document community perceptions of maternal immunization, using tetanus vaccine as an example, and to identify factors perceived to be important to successfully introducing other maternal vaccines, such as influenza vaccine, in Malawi. We conducted 18 focus group discussions with pregnant and recently pregnant women and their family members and 76 semi-structured interviews with pregnant and recently pregnant women, community leaders, health workers, public health program managers, non-governmental partners, and policy makers.

resultsWe identified factors perceived to support the introduction of new maternal vaccines, including strong maternal vaccine acceptance in the community, an existing strategy for maternal tetanus vaccine delivery, and positive health workers' views about the introduction of additional maternal vaccines. Potential challenges to adoption and acceptance included identifying and tracking the target population and monitoring adverse events, and the need to ensure operational capacity of the health system to support the introduction and wide-scale use of an additional vaccine. For influenza vaccine specifically, additional challenges included limited awareness of influenza disease and its low prioritization among health needs.

conclusionsLessons from the successful delivery of maternal tetanus immunization in Malawi may be informative for similar countries considering new vaccines for pregnant women or striving to optimize the delivery of those currently provided.

Indexed as

AdolescentAdultFemaleHealth PersonnelHumansImmunizationMalawiMiddle AgedPatient Acceptance of Health CarePregnancyPregnancy Complications, InfectiousPregnant PeopleVaccinationVaccinesYoung AdultVaccinesMalawiMaternal immunizationMaternal tetanus toxoid and maternal influenza vaccineOperational research

Identifiers

PMID31319932
PMCPMC6642336
OpenAlexW2959312171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.