ArticleParticle and fibre toxicology2019
Titanium dioxide nanoparticles oral exposure to pregnant rats and its distribution.
Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Organ and tissue accumulation of titanium dioxide after acute, subacute, subchronic, and chronic oral exposure in mice and rats: a systematic review.Particle and fibre toxicology · 2026Pooled it
- Gestational Intranasal Exposure to Silicon Dioxide Nanoparticles in Rats.International journal of nanomedicine · 2026Article
- Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025Review
- In Utero Nano-Titanium Dioxide Exposure Results in Sexually Dimorphic Weight Gain and Cardiovascular Function in Offspring.Cardiovascular toxicology · 2025Article
- Hepatotoxicity of titanium dioxide nanoparticles.Journal of applied toxicology : JAT · 2025Review
- Titanium Dioxide Nanoparticles Induce Cell Cycle Arrest and Apoptosis through Inhibiting PI3K/AKT/mTOR Pathway in Spermatogonia.Biological trace element research · 2024Article
- Biomedical application of TiOCell biology and toxicology · 2024Article
- Advanced Nanostructured Coatings Based on Doped TiOMolecules (Basel, Switzerland) · 2023Review
- Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles.Nature communications · 2023Article
- Article
- Study of the Embryonic Toxicity of TiOMicromachines · 2023Article
- Genetic effects of chemically and biosynthesized titanium dioxide nanoparticlesFrontiers in veterinary science · 2023Article
- Ingestion of titanium dioxide nanoparticles: a definite health risk for consumers and their progeny.Archives of toxicology · 2022Review
- Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles-A Systematic Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Reproductive and developmental toxicity screening test of new TiO2 GST in Sprague-Dawley rats.Environmental analysis, health and toxicology · 2022Article
- Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring.Particle and fibre toxicology · 2022Article
- Applications of Titanium Dioxide Nanostructure in Stomatology.Molecules (Basel, Switzerland) · 2022Review
- Teratological effects of titanium dioxide nanoparticles in mice embryo.Environmental science and pollution research international · 2022Article
- Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy.Placenta · 2022Article
- Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring.Journal of nanobiotechnology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium dioxide (TiO
resultsIn the maternal and embryo-fetal examinations, there were no marked toxicities in terms of general clinical signs, body weight, food consumption, organ weights, macroscopic findings, cesarean section parameters and fetal morphological examinations. In the distribution analysis, titanium contents were increased in the maternal liver, maternal brain and placenta after exposure to high doses of TiO
conclusionOral exposure to TiO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.