Evidence map›Paper›PMID 31319809›Full record

ArticleBMC geriatrics2019

A multicenter cohort study to investigate the factors associated with functional autonomy change in patients with cognitive complaint or neurocognitive disorders: the MEMORA study protocol.

Virginie Dauphinot, Claire Moutet, Isabelle Rouch, Mathieu Verdurand, Christelle Mouchoux, Floriane Delphin-Combe, Sylvain Gaujard, Pierre Krolak-Salmon, MEMORA group

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02302482 (Predictive Factors of the Autonomy Level Change Related to Memory Disorders), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02302482 narecruitingnot on this map

Predictive Factors of the Autonomy Level Change Related to Memory Disorders

TypeinterventionalSponsorHospices Civils de LyonRan2014 to 2027Enrolled10,860ConditionsMemory ImpairmentArmsThe Lawton Instrumental Activities of Daily Living score (IADL), and the disability assessment of dementia score (DAD-6
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Virginie DauphinotCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France. d_virginie@hotmail.com.ORCID 0000-0001-5020-2864
Claire MoutetCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
Isabelle RouchCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
Mathieu VerdurandCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
Christelle MouchouxInstitut du Vieillissement I-Vie, Hospices Civils de Lyon, Lyon, France.
Floriane Delphin-CombeCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
Sylvain GaujardCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
Pierre Krolak-SalmonCentre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
MEMORA group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe identification of factors associated with functional impairment, in particular those which are potentially modifiable, may help to delay the advanced stages of functional dependence in patients with neurocognitive disorders such as Alzheimer's disease and related disorders. The objectives of the MEMORA cohort are to investigate the factors associated, first with functional autonomy change over time, and secondarily with the cognitive performance and behavioral disorders changes over time.

methodsThe MEMORA study is a multicenter prospective cohort study carried out throughout the patient's care pathway, in Memory centers of Lyon (France). The study will include 6780 patients at all stages of memory disorders in 6 years. The follow-up for each patient is planned for 3 years. The main outcome is the functional autonomy level change as assessed by the instrumental abilities of daily living (IADL) score. Patient characteristics include sociodemographic and clinical features, neuropsychological performance, pharmaceutical and non-pharmaceutical therapy. DISCUSSION: This study conducted in a context of routine care may help to identify the factors associated with functional impairment related to progressive neurocognitive disorders. Subsequently, interventions on potentially modifiable factors could be proposed to the patients to improve their management and delay functional dependence.

trial registrationNCT02302482 , registered 27 November 2014.

Indexed as

CognitionNeurocognitive DisordersNeuropsychological TestsActivities of Daily LivingAgedAged, 80 and overClinical Trials as TopicCohort StudiesFemaleFollow-Up StudiesFranceHumansMaleMemory DisordersMulticenter Studies as TopicProspective StudiesActivity of daily livingLongitudinal studyMemoryNeurocognitive disorders

Identifiers

PMID31319809
PMCPMC6637582

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.