Evidence map›Paper›PMID 31319636›Full record

ArticleGenes2019

Genetic Analyses of Tanzanian Local Chicken Ecotypes Challenged with Newcastle Disease Virus.

Muhammed Walugembe, James R Mushi, Esinam N Amuzu-Aweh, Gaspar H Chiwanga, Peter L Msoffe, Ying Wang, Perot Saelao, Terra Kelly, Rodrigo A Gallardo, Huaijun Zhou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Muhammed WalugembeDepartment of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA.
James R MushiDepartment of Veterinary Medicine and Public Health, Sokoine University, P.O. Box 3000 Chuo Kikuu, Morogoro, Tanzania.
Esinam N Amuzu-AwehDepartment of Animal Science, University of Ghana, P.O. Box LG 25 Legon, Accra, Ghana.
Gaspar H ChiwangaDepartment of Veterinary Medicine and Public Health, Sokoine University, P.O. Box 3000 Chuo Kikuu, Morogoro, Tanzania.
Peter L MsoffeDepartment of Veterinary Medicine and Public Health, Sokoine University, P.O. Box 3000 Chuo Kikuu, Morogoro, Tanzania.
Ying WangDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Perot SaelaoDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Terra KellyDepartment of Animal Science, University of California, Davis, CA 95616, USA.ORCID 0000-0001-6762-7885
Rodrigo A GallardoSchool of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Huaijun ZhouDepartment of Animal Science, University of California, Davis, CA 95616, USA.ORCID 0000-0001-6023-9521
Susan J LamontDepartment of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA.
Amandus P MuhairwaDepartment of Veterinary Medicine and Public Health, Sokoine University, P.O. Box 3000 Chuo Kikuu, Morogoro, Tanzania. apm@suanet.ac.tz.
Jack C M DekkersDepartment of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA. jdekkers@iastate.edu.
University of California, Davis · USSokoine University of Agriculture · TZIowa State University · USUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Newcastle Disease (ND) is a continuing global threat to domestic poultry, especially in developing countries, where severe outbreaks of velogenic ND virus (NDV) often cause major economic losses to households. Local chickens are of great importance to rural family livelihoods through provision of high-quality protein. To investigate the genetic basis of host response to NDV, three popular Tanzanian chicken ecotypes (regional populations) were challenged with a lentogenic (vaccine) strain of NDV at 28 days of age. Various host response phenotypes, including anti-NDV antibody levels (pre-infection and 10 days post-infection, dpi), and viral load (2 and 6 dpi) were measured, in addition to growth rate. We estimated genetic parameters and conducted genome-wide association study analyses by genotyping 1399 chickens using the Affymetrix 600K chicken SNP chip. Estimates of heritability of the evaluated traits were moderate (0.18-0.35). Five quantitative trait loci (QTL) associated with growth and/or response to NDV were identified by single-SNP analyses, with some regions explaining ≥1% of genetic variance based on the Bayes-B method. Immune related genes, such as ETS1, TIRAP, and KIRREL3, were located in regions associated with viral load at 6 dpi. The moderate estimates of heritability and identified QTL indicate that NDV response traits may be improved through selective breeding of chickens to enhance increased NDV resistance and vaccine efficacy in Tanzanian local ecotypes.

Indexed as

EcotypeNewcastle disease virusAnimalsChickensComputational BiologyGenomeGenome-Wide Association StudyGenomicsGenotypeHost-Pathogen InteractionsNewcastle DiseasePhenotypePolymorphism, Single NucleotidePoultry DiseasesQuantitative Trait LociGWASimmune responseNDVQTLTanzanian local ecotypes

Identifiers

PMID31319636
PMCPMC6678660
OpenAlexW2961973411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.