Evidence map›Paper›PMID 31319608›Full record

ArticleBiomolecules2019

Caveolin-1 Endows Order in Cholesterol-Rich Detergent Resistant Membranes.

Carla Raggi, Marco Diociaiuti, Giulio Caracciolo, Federica Fratini, Luca Fantozzi, Giovanni Piccaro, Katia Fecchi, Elisabetta Pizzi, Giuseppe Marano, Fiorella Ciaffoni and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Peripheral myelin protein 22 preferentially partitions into ordered phase membrane domains.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Review
  8. Review
  9. Targeting Lipid Rafts as a Strategy Against Coronavirus.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Carla RaggiNational Center for Control and Evaluation of Medicines, Istituto Superiore di Sanità, 00161 Rome, Italy.
Marco DiociaiutiNational Center for Rare Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
Giulio CaraccioloDepartment of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy.
Federica FratiniScientific Service for Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.
Luca FantozziPresent address : ARPALAZIO, Via Salaria per L'Aquila 6/8, 02100 Rieti, Italy.
Giovanni PiccaroNotified Body, Istituto Superiore di Sanità, 00161 Rome, Italy.
Katia FecchiReference Centre for Gender Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Elisabetta PizziScientific Service for Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.
Giuseppe MaranoReference Centre for Gender Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Fiorella CiaffoniScientific Service for Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.
Elena BravoScientific Service for Research Coordination and Support, Istituto Superiore di Sanità, 00161 Rome, Italy.
Maria L FianiNational Center for Global Health, Istituto Superiore di Sanità, 00161 Rome, Italy. maria.fiani@iss.it.
Massimo SargiacomoNational Center for Global Health, Istituto Superiore di Sanità, 00161 Rome, Italy. massimo.sargiacomo@iss.it.
Istituto Superiore di Sanità · ITSapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesterol-enriched functional portions of plasma membranes, such as caveolae and rafts, were isolated from lungs of wild-type (WT) and caveolin-1 knockout (Cav-1 KO) mice within detergent resistant membranes (DRMs). To gain insight into their molecular composition we performed proteomic and lipid analysis on WT and Cav-1 KO-DRMs that showed predicted variations of proteomic profiles and negligible differences in lipid composition, while Langmuir monolayer technique and small and wide-angle X-ray scattering (SAXS-WAXS) were here originally introduced to study DRMs biophysical association state. Langmuir analysis of Cav-1 containing DRMs displayed an isotherm with a clear-cut feature, suggesting the coexistence of the liquid-ordered (

Indexed as

AnimalsCaveolaeCaveolin 1CholesterolHumansProteomicsX-Ray DiffractionCaveolin 1Cholesterolcaveolaecholesterol-rich microdomainsLangmuir filmslipid raftsliquid ordermembrane heterogeneitymembranes/fluiditymembranes/model lipid-raftsmembranes/physical chemistryX-ray diffraction

Identifiers

PMID31319608
PMCPMC6680987
OpenAlexW2959238846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.