ArticleInternational journal of molecular sciences2019
Social Defeat Modulates T Helper Cell Percentages in Stress Susceptible and Resilient Mice.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Social status impacts T-cell responses through synapse strength in the prefrontal cortex.Cell research · 2026Article
- Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response.Biology of sex differences · 2026Article
- Emotional pain in non-human mammals: from neural circuitry and opioid signaling to dysthymia-like states, grief-like behaviors, and physiological dysregulation.Frontiers in veterinary science · 2026Review
- The emerging role of T cells in depression.Frontiers in psychiatry · 2026Review
- Astrocyte Ezrin defines resilience to stress-induced depressive behaviours in mice.National science review · 2026Article
- The multifaceted impact of stress on immune function.Molecular biology reports · 2025Review
- Modulation of neuroimmune cytokine networks by antidepressants: implications in mood regulation.Translational psychiatry · 2025Review
- The microbiota-gut-brain axis in depression: unraveling the relationships and therapeutic opportunities.Frontiers in immunology · 2025Review
- Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors.Brain, behavior, and immunity · 2025Article
- The impact of BDNF and CD4 + T cell crosstalk on depression.Immunologic research · 2024Article
- Body mass, neuro-hormonal stress processing, and disease activity in lean to obese people with multiple sclerosis.Journal of neurology · 2024Article
- Innate and adaptive immune system consequences of post-traumatic stress disorder.Autonomic neuroscience : basic & clinical · 2024Review
- Research progress on the correlation between transforming growth factor-Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin.Neuronal signaling · 2023Review
- Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain.Journal of neuroinflammation · 2022Article
- Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells.Scientific reports · 2022Article
- Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells.Pharmacological reviews · 2022Review
- Immunological and psychosocial functioning in parents of children with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut-brain communications.Frontiers in immunology · 2022Review
- Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Altered adaptive immunity involving T lymphocytes has been found in depressed patients and in stress-induced depression-like behavior in animal models. Peripheral T cells play important roles in homeostasis and function of the central nervous system and thus modulate behavior. However, the T cell phenotype and function associated with susceptibility and resilience to depression remain largely unknown. Here, we characterized splenic T cells in susceptible and resilient mice after 10 days of social defeat stress (SDS). We found equally decreased T cell frequencies and comparably altered expression levels of genes associated with T helper (Th) cell function in resilient and susceptible mice. Interleukin (IL)-17 producing CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.