Evidence map›Paper›PMID 31319489›Full record

ArticleInternational journal of molecular sciences2019

Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria.

Noriyuki Akahoshi, Hiroki Handa, Rintaro Takemoto, Shotaro Kamata, Masahide Yoshida, Tatsushi Onaka, Isao Ishii

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Hydrogen sulfide and its role in female reproduction.Frontiers in veterinary science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Noriyuki AkahoshiDepartment of Health Chemistry, Showa Pharmaceutical University, Tokyo 194-8543, Japan.
Hiroki HandaDepartment of Health Chemistry, Showa Pharmaceutical University, Tokyo 194-8543, Japan.
Rintaro TakemotoDepartment of Health Chemistry, Showa Pharmaceutical University, Tokyo 194-8543, Japan.
Shotaro KamataDepartment of Health Chemistry, Showa Pharmaceutical University, Tokyo 194-8543, Japan.
Masahide YoshidaDepartment of Physiology, Jichi Medical University, Tochigi 329-0498, Japan.
Tatsushi OnakaDepartment of Physiology, Jichi Medical University, Tochigi 329-0498, Japan.
Isao IshiiDepartment of Health Chemistry, Showa Pharmaceutical University, Tokyo 194-8543, Japan. isao-ishii@umin.ac.jp.ORCID 0000-0002-5367-205X
Showa Pharmaceutical University · JPJichi Medical University · JP

Funding

Japan Society for the Promotion of Science 16H05107Japan Society for the Promotion of Science 17K08287
6 · The paper itself

Abstract

Elevated plasma homocysteine levels are considered as a risk factor for cardiovascular diseases as well as preeclampsia-a pregnancy disorder characterized by hypertension and proteinuria. We previously generated mice lacking cystathionine γ-lyase (Cth) as cystathioninuria models and found them to be with cystathioninemia/homocysteinemia. We investigated whether Cth-deficient (

Indexed as

HyperhomocysteinemiaLactation DisordersPre-EclampsiaAnimalsCystathionine gamma-LyaseDisease Models, AnimalFemaleMiceMice, KnockoutPregnancyCystathionine gamma-Lyasecystathionine γ-lyasehomocysteinehypertensionmilk ejectionoxytocinpreeclampsiaproteinuria

Identifiers

PMID31319489
PMCPMC6679037
OpenAlexW2958853114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.