Evidence map›Paper›PMID 31319464›Full record

ArticleInternational journal of molecular sciences2019

Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing.

Li Xie, Lei Xie

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Antifungal potential of multi-drug-resistantFrontiers in cellular and infection microbiology · 2024
    Article
  3. Drug repositioning: A bibliometric analysis.Frontiers in pharmacology · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Li XieDepartment of Computer Science, Hunter College, The City University of New York, New York, NY 10065, USA.
Lei XieDepartment of Computer Science, Hunter College, The City University of New York, New York, NY 10065, USA. lei.xie@hunter.cuny.edu.ORCID 0000-0001-9051-2111
The Graduate Center, CUNY · US

Funding

Omics data integration and analysis for structure-based multi-target drug designR01GM122845 · NIGMS · NORTHEASTERN UNIVERSITY · PI Lei Xie · 2017 to 2026
$3.0M
Drug discovery by integrating chemical genomics and structural systems biologyR01LM011986 · NLM · HUNTER COLLEGE · PI BRINKMAN, FIONA, BURLEY, STEPHEN K · 2014 to 2017
$1.2M
Anti-virulence drug repurposing using structural systems pharmacologyR21TR001722 · NCATS · HUNTER COLLEGE · PI XIE, LEI · 2016 to 2017
$643k
NCATS NIH HHS R21 TR001722NCATS NIH HHS R21TR001722NIGMS NIH HHS R01 GM122845NIGMS NIH HHS R01GM122845NLM NIH HHS R01LM011986
6 · The paper itself

Abstract

The emergence of superbugs that are resistant to last-resort antibiotics poses a serious threat to human health, and we are in a "race against time to develop new antibiotics." New approaches are urgently needed to control drug-resistant pathogens, and to reduce the emergence of new drug-resistant microbes. Targeting bacterial virulence has emerged as an important strategy for combating drug-resistant pathogens. It has been shown that pyocyanin, which is produced by the phenazine biosynthesis pathway, plays a key role in the virulence of

Indexed as

Drug DesignDrug DiscoveryDrug RepositioningMolecular Docking SimulationAnti-Bacterial AgentsHumansAnti-Bacterial Agentsphenazine biosynthesis pathwaypolypharmacologyprotein–ligand dockingstructure-based drug designvirtual screening

Identifiers

PMID31319464
PMCPMC6678309
OpenAlexW2961263108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.