Evidence map›Paper›PMID 31319359›Full record

ArticleInternational immunopharmacology2019

Combination of acute intravenous methamphetamine injection and LPS challenge facilitate leukocyte infiltration into the central nervous system of C57BL/6 mice.

Daniela DiCaro, Hiu Ham Lee, Christian Belisario, Raddy L Ramos, Luis R Martinez

Abstract read
In one paragraph

Article in International immunopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Role of Microglia in Psychostimulant Addiction.Current neuropharmacology · 2023
    Review
  3. Article
  4. Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.The Journal of pharmacology and experimental therapeutics · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniela DiCaroDepartment of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA.
Hiu Ham LeeDepartment of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA.
Christian BelisarioDepartment of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA.
Raddy L RamosDepartment of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA.
Luis R MartinezDepartment of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, TX, USA. Electronic address: lmartinez43@utep.edu.

Funding

TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
Impact of Methamphetamine Induced IL-6 Production on Wound Healing and InflammationR15GM117501 · NIGMS · NEW YORK INST OF TECHNOLOGY · PI RAMOS, RADDY LEONARDO · 2016 to 2016
$432k
NIGMS NIH HHS R15 GM117501NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

Methamphetamine (METH) is a stimulant of the central nervous system (CNS) that causes behavioral changes in users. METH is slowly cleared from brain tissue and its chronic use is neurotoxic. METH also alters the cellular and chemical components of inflammation. However, little is known about the effect of a single intravenous dose of METH followed by bacterial lipopolysaccharide (LPS) injection on cellular infiltration and cytokine release in brain tissue. Using a murine model of acute METH administration and flow cytometry, we found that combination of METH and LPS stimulate the infiltration of macrophages (F4/80

Indexed as

AnimalsBrainCentral Nervous System StimulantsCytokinesFemaleInjections, IntravenousLeukocytesLipopolysaccharidesMaleMethamphetamineMice, Inbred C57BLCentral Nervous System StimulantsCytokinesLipopolysaccharidesMethamphetamineCytokinesInflammationMacrophagesMethamphetamineNeutrophils

Identifiers

PMID31319359
PMCPMC6905393

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.