Evidence map›Paper›PMID 31319351›Full record

ArticleCarbohydrate research2019

The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1→4GlcNAcβ1→3Galβ1→4Glc).

Mithila D Bandara, Keith J Stine, Alexei V Demchenko

Open access · greenAbstract read
In one paragraph

Article in Carbohydrate research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

  1. Identification of a novel β-1,4-galactosyltransferase fromSynthetic and systems biotechnology · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
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  11. Synthesis as an Expanding Resource in Human Milk Science.Journal of the American Chemical Society · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Chemical Synthesis of Human Milk Oligosaccharides: Lacto-The Journal of organic chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mithila D BandaraDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.
Keith J StineDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.
Alexei V DemchenkoDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA. Electronic address: demchenkoa@umsl.edu.
University of Missouri–St. Louis · US

Funding

Refinement and implementation of the automated oligosaccharide synthesizerU01GM120673 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI DE MEO, CRISTINA, DEMCHENKO, ALEXEI V · 2016 to 2019
$2.2M
NIGMS NIH HHS U01 GM120673
6 · The paper itself

Abstract

The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has been completed using both linear and convergent strategies. The donor and acceptor protecting and leaving group combinations were found to be of paramount significance to successful couplings.

Indexed as

Carbohydrate SequenceChemical PhenomenaHumansMilk, HumanOligosaccharideslacto-N-neotetraoseOligosaccharides

Identifiers

PMID31319351
PMCPMC6717531
OpenAlexW4242174618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.