ArticleJournal of affective disorders2019
Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta-analysis of the Literature.Neurochemical research · 2021Pooled it
- Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial.Molecular psychiatry · 2021Trial
- Trial
- The predictive value of niacin skin flushing response and inflammatory factors for the antidepressant efficacy.BMC psychiatry · 2026Article
- Metabolic profiling reveals potential biomarkers and underlying signaling pathways involved in mindfulness-based cognitive therapy-improved adolescent depression symptoms.EXCLI journal · 2026Article
- Transformations in plasma metabolic profiles of patients with major depression disorder during treatment.Metabolic brain disease · 2025Article
- Abnormalities of lipid metabolism in the progression and treatment of depression.Frontiers in psychiatry · 2025Review
- The effect of greater occipital nerve block on amplification of somatic symptoms and anxiety and depression levels in chronic migraine.Acta neurologica Belgica · 2024Article
- Effect of Shenqi Jieyu formula on inflammatory response pathway in hippocampus of postpartum depression rats.Heliyon · 2024Article
- Can essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?Lipids in health and disease · 2024Review
- The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk.Molecular psychiatry · 2024Review
- Association between plasma polyunsaturated fatty acids and depressive among US adults.Frontiers in nutrition · 2024Article
- Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders.medRxiv : the preprint server for health sciences · 2023Article
- Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Review
- Pathophysiological mechanisms of post-myocardial infarction depression: a narrative review.Frontiers in psychiatry · 2023Review
- Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy.Molecular psychiatry · 2022Article
- The antidepressant effects and serum metabonomics of bifid triple viable capsule in a rat model of chronic unpredictable mild stress.Frontiers in nutrition · 2022Article
- Naturally absorbed lithium may prevent suicide attempts and deliberate self-harm while eicosapentaenoic acid may prevent deliberate self-harm and arachidonic acid may be a risk factor for deliberate self-harm: The updated different findings in new analyses.Frontiers in psychiatry · 2022Article
- Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats.Frontiers in pharmacology · 2022Article
- DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.Nutrients · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundSerotonin transporter (5-HTT) binding and polyunsaturated fatty acids (PUFAs) are implicated in major depressive disorder (MDD). Links between the two systems in animal models have not been investigated in humans.
methodsUsing positron emission tomography (PET) and [
resultsAA predicted both 5-HTT BP LIMITATIONS: Given the small sample and multiple comparisons, results require replication.
conclusionsOur findings suggest that AA status may impact depression pathophysiology through effects on serotonin transport. Future studies should examine whether these relationships explain therapeutic effects of PUFAs in the treatment of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.