Evidence map›Paper›PMID 31319222›Full record

ArticleThe journal of allergy and clinical immunology. In practice2020

Oral challenge with trimethoprim-sulfamethoxazole in patients with "sulfa" antibiotic allergy.

Matthew S Krantz, Cosby A Stone, Andrew Abreo, Elizabeth J Phillips

Open access · greenAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 59 citations in OpenAlex.

  1. Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Point prevalence survey of antibiotic allergies in hospitalized patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  7. A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions.Transplant infectious disease : an official journal of the Transplantation Society · 2024
    Review
  8. Article
  9. How to Define and Manage Low-Risk Drug Allergy Labels.The journal of allergy and clinical immunology. In practice · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Safety and value of pretransplant antibiotic allergy delabeling in a quaternary transplant center.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  15. Article
  16. Review
  17. Sulfonamide Hypersensitivity.Clinical reviews in allergy & immunology · 2022
    Review
  18. Article
  19. Non-IgE-Mediated Drug Hypersensitivity Reactions.Current allergy and asthma reports · 2021
    Review
  20. Outcome of trimethoprim-sulfamethoxazole challenge in previously reported patients with sulfa antibiotic allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Matthew S KrantzDepartments of Medicine and Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.
Cosby A StoneDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
Andrew AbreoDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
Elizabeth J PhillipsDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia. Electronic address: elizabeth.j.phillips@vanderbilt.edu.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2015 to 2019
$13.0M
CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4M
Single Cell definition of pathogenic T cells in Drug-induced Stevens-Johnson-Syndrome/Toxic epidermal necrolysisR21AI139021 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2018 to 2019
$435k
NATIENS: A Phase III Randomized Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal NecrolysisR34AI136815 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2018 to 2018
$205k
NIAID NIH HHS R21 AI139021NIAID NIH HHS R34 AI136815NIGMS NIH HHS P50 GM115305NIGMS NIH HHS T32 GM007569
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug HypersensitivityTrimethoprim, Sulfamethoxazole Drug CombinationAnti-Bacterial AgentsDrug CombinationsHumansSulfonamidesAnti-Bacterial AgentsDrug CombinationsSulfonamidesTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID31319222
PMCPMC6960372
OpenAlexW2961830492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.